Description

Diisopropylethylamine trihydrofluoride (CAS No. 131600-43-6) is a high-purity organic salt with the molecular formula C₈H₂₂F₃N, widely used in pharmaceutical and chemical synthesis as a fluorinating agent and base. This compound is a trihydrofluoride salt of diisopropylethylamine (DIPEA), offering enhanced stability and reactivity for demanding applications. With a carefully controlled synthesis process, our product delivers consistent performance in nucleophilic fluorination reactions, deprotection of silyl groups, and as a mild source of fluoride ions. Its low nucleophilicity and high solubility in organic solvents make it ideal for specialized reactions in medicinal chemistry and material science. Packaged under inert conditions to ensure maximum shelf life, this reagent is a reliable choice for researchers requiring precise fluorination control.

Properties

• CAS Number: 131600-43-6
• Complexity: 59
• IUPAC Name: N-ethyl-N-isopropyl-propan-2-amine;trihydrofluoride
• InChI: InChI=1S/C8H19N.3FH/c1-6-9(7(2)3)8(4)5;;;/h7-8H,6H2,1-5H3;3*1H
• InChI Key: AJRRXKJZYYBJPY-UHFFFAOYSA-N
• Exact Mass: 189.17043419
• Molecular Formula: C8H22F3N
• Molecular Weight: 189.26
• SMILES: CCN(C(C)C)C(C)C.F.F.F
• Topological: 3.2
• Monoisotopic Mass: 189.17043419
• Synonyms: 131600-43-6, Diisopropylethylamine trihydrofluoride, N-Ethyl-N-isopropylpropan-2-amine trihydrofluoride, N,N-Diisopropylethylamine trihydrofluoride, 2-Propanamine, N-ethyl-N-(1-methylethyl)-, hydrofluoride (1:3), MFCD00144880, C8H22F3N, SCHEMBL73855, DTXSID70668257, AJRRXKJZYYBJPY-UHFFFAOYSA-N, AKOS015915444, AS-75528, SY067531, N,N,-diisopropylethylamine trihydrofluoride, DB-062832, E77914, N-Ethyl-N-isopropyl-2-propanamine Trihydrofluoride, N-Ethyl-N-(propan-2-yl)propan-2-amine–hydrogen fluoride (1/3)

Diisopropylethylamine trihydrofluoride is primarily used as a fluorinating agent in organic synthesis, particularly for nucleophilic substitutions and deprotections. It serves as a mild alternative to aggressive fluorination reagents, enabling selective transformations in sensitive substrates. Applications include peptide synthesis, where it assists in deprotecting tert-butyloxycarbonyl (Boc) groups, and in material science for modifying surfaces with fluorine. Its stability and solubility also make it valuable in electrochemical fluorination processes.

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