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Atomfair 7-Bromo-2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine C6H2BrCl2N3 CAS 1311275-27-0

7-Bromo-2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine (CAS No. 1311275-27-0) is a high-purity heterocyclic compound with the molecular formula C6H2BrCl2N3. This brominated and chlorinated pyrrolopyrimidine derivative is a valuable building block in medicinal chemistry and pharmaceutical research, particularly in the synthesis of kinase inhibitors and other biologically active molecules. The compound features a fused bicyclic structure with reactive halogen substituents at the 2, 4, and 7 positions, enabling versatile functionalization via cross-coupling reactions. Supplied as an off-white to light brown crystalline powder, it is characterized by excellent batch-to-batch consistency (>95% purity by HPLC). Proper storage under inert atmosphere at 2-8°C is recommended to maintain stability. This…

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Description

7-Bromo-2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine (CAS No. 1311275-27-0) is a high-purity heterocyclic compound with the molecular formula C6H2BrCl2N3. This brominated and chlorinated pyrrolopyrimidine derivative is a valuable building block in medicinal chemistry and pharmaceutical research, particularly in the synthesis of kinase inhibitors and other biologically active molecules. The compound features a fused bicyclic structure with reactive halogen substituents at the 2, 4, and 7 positions, enabling versatile functionalization via cross-coupling reactions. Supplied as an off-white to light brown crystalline powder, it is characterized by excellent batch-to-batch consistency (>95% purity by HPLC). Proper storage under inert atmosphere at 2-8°C is recommended to maintain stability. This product is intended for research purposes only and is not for human or veterinary use.

Properties

  • CAS Number: 1311275-27-0
  • Complexity: 182
  • IUPAC Name: 7-bromo-2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine
  • InChI: InChI=1S/C6H2BrCl2N3/c7-2-1-10-4-3(2)11-6(9)12-5(4)8/h1,10H
  • InChI Key: JGTLHNZGTGLLAD-UHFFFAOYSA-N
  • Exact Mass: 264.88092
  • Molecular Formula: C6H2BrCl2N3
  • Molecular Weight: 266.91
  • SMILES: C1=C(C2=C(N1)C(=NC(=N2)Cl)Cl)Br
  • Topological: 41.6
  • Monoisotopic Mass: 264.88092
  • Synonyms: 7-Bromo-2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine, 1311275-27-0, 5H-Pyrrolo[3,2-d]pyrimidine, 7-bromo-2,4-dichloro-, SCHEMBL20524214, LCC27527, AKOS015835826, AT32691, CS-0242829, EN300-255826, Z1269208820

Application

7-Bromo-2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine serves as a key intermediate in the synthesis of purine-like heterocycles for drug discovery programs. Its reactive halogen sites allow for sequential functionalization via Suzuki, Buchwald-Hartwig, or nucleophilic aromatic substitution reactions. Researchers utilize this scaffold in developing ATP-competitive kinase inhibitors targeting various disease pathways. The compound has shown particular utility in constructing analogs for JAK and CDK inhibitor development.

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

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  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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