Description

Pamoic Acid (CAS 130-85-8) is a high-purity naphthalene-based dicarboxylic acid with the molecular formula C₂₃H₁₆O₆. Also known as Embonic Acid, this compound is characterized by its distinct yellow crystalline powder form and low solubility in water, making it ideal for specialized applications in pharmaceutical salt formation and analytical chemistry. Its IUPAC name, 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid, reflects its bifunctional structure with hydroxyl and carboxyl groups, enabling versatile reactivity. Pamoic Acid is rigorously tested for purity (typically ≥98% by HPLC) and is supplied with detailed analytical certificates (COA) to ensure compliance with research and industrial standards. Suitable for use as a counterion in drug formulation, this product is packaged under inert conditions to guarantee stability.

Properties

• CAS Number: 130-85-8
• Complexity: 568
• IUPAC Name: 4-[(3-carboxy-2-hydroxy-1-naphthyl)methyl]-3-hydroxy-naphthalene-2-carboxylic acid
• InChI: InChI=1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29)
• InChI Key: WLJNZVDCPSBLRP-UHFFFAOYSA-N
• Exact Mass: 388.09468823
• Molecular Formula: C23H16O6
• Molecular Weight: 388.4
• SMILES: C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O
• Topological: 115
• Monoisotopic Mass: 388.09468823
• Synonyms: PAMOIC ACID, 130-85-8, Embonic acid, 4,4′-Methylenebis(3-hydroxy-2-naphthoic acid), Pamosaeure, 2-Naphthalenecarboxylic acid, 4,4′-methylenebis[3-hydroxy-, 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid, EINECS 204-998-0, 7RRQ8QZ38N, NSC 30188, NSC-30188, BRN 0901319, DTXSID9048984, CHEBI:50186, AI3-14604, 2-Naphthalenecarboxylic acid, 4,4′-methylenebis(3-hydroxy-, 4,4′-methylenebis(3-hydroxy-2-naphthalenecarboxylic acid), 4,4′-methylenedi(3-hydroxy-2-naphthoic acid), PAMOIC ACID [MI], 4,4′-Methylen-bis-(3-hydroxy-2-naphthoesaeure, 2-Naphthoic acid, 4,4′-methylenebis(3-hydroxy-, 3,3′-Dihydroxy-4,4′-methylenedi(2-naphthoic acid), PAMOIC ACID [USP-RS], PAMOIC ACID [WHO-DD], 1,1′-Dinaphthylmethan-2,2′-dihydroxy-3,3′-dicarbonsaeure, DTXCID9028910, 4,4′-Methylen-bis-(3-hydroxy-2-naphthoesaeure), 4-10-00-02362 (Beilstein Handbook Reference), 4,4′-methylenebis(3-hydroxynaphthalene-2-carboxylic acid), PAMOIC ACID (USP-RS), 4,4′-methanediylbis(3-hydroxynaphthalene-2-carboxylic acid), 4-((3-carboxy-2-hydroxynaphthalen-1-yl)methyl)-3-hydroxynaphthalene-2-carboxylic acid, 4,4′-methylenebis(3-hydroxy)-2-naphthoic acid naphthalenecarboxylic acid, 685-649-3, NSC30188, MFCD00004079, 1,1′-Methylene-bis(2-hydroxy-3-naphthoic acid), CHEMBL177880, NCGC00013369-03, 4-[(3-carboxy-2-oxidanyl-naphthalen-1-yl)methyl]-3-oxidanyl-naphthalene-2-carboxylic acid, SMR000544945, 2-Naphthoic acid,4′-methylenebis[3-hydroxy-, C23H16O6, UNII-7RRQ8QZ38N, 2-Naphthalenecarboxylic acid,4′-methylenebis[3-hydroxy-, Pamoic acid 98+% (HPLC), JBR, Embonic acid, 98%, Pamoic acid (Standard), Embonic acid, Pamoic acid, SCHEMBL5721, NCIStruc1_001097, NCIStruc2_001188, Oprea1_344667, cid_25096, MLS004773913, MLS006011716, GTPL2920, BDBM38549, HMS3749I13, Pamoic acid, >=97.0% (T), BCP17325, CS-B1767, HY-W008613R, NCI30188, NSC40132, Tox21_113446, AC8068, CCG-37117, NCGC00013369, NSC-40132, STK793148, AKOS002347371, FP26746, HY-W008613, KS-5172, 4-[(3-carboxy-2-hydroxy-1-naphthyl)methyl]-3-hydroxy-naphthalene-2-carboxylic acid, NCGC00013369-02, NCGC00013369-07, NCGC00096485-01, NCGC00096485-02, CAS-130-85-8, NCI60_002537, SY038966, DB-014958, DS-005180, NS00005701, P0761, ST50307984, L019618, Q411413, BRD-K82118441-001-03-7, 4,4?-METHYLENEBIS(3-HYDROXY-2-NAPHTHOIC ACID), 2,2′-Dihydroxy-1,1′-dinaphthylmethane-3,3′-dicarboxylic acid, 4,4′-Methylenebis(3-hydroxy-2-naphthoic acid);Embonic acid, Pamoic acid, United States Pharmacopeia (USP) Reference Standard, 4,4 inverted exclamation mark -Methylenebis(3-hydroxy-2-naphthoic Acid), Pamoic Acid, Pharmaceutical Secondary Standard; Certified Reference Material, 4-[(3-carboxy-2-hydroxynaphthyl)methyl]-3-hydroxynaphthalene-2-carboxylic acid, 108626-78-4, 4-[(3-carboxy-2-hydroxy-1-naphthalenyl)methyl]-3-hydroxy-2-naphthalenecarboxylic acid;2-[2-[4-[(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]ethanol, 4-[(3-carboxy-2-hydroxy-1-naphthyl)methyl]-3-hydroxy-2-naphthoic acid;2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino]ethoxy]ethanol, 4-[(3-carboxy-2-oxidanyl-naphthalen-1-yl)methyl]-3-oxidanyl-naphthalene-2-carboxylic acid;2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]ethanol

Application

Pamoic Acid is widely utilized as a precipitating agent for the formation of poorly soluble salts (pamoates) in pharmaceutical formulations, extending drug release profiles. It serves as a key intermediate in synthesizing metal-organic frameworks (MOFs) due to its chelating properties. Researchers also employ it in chromatography as a derivatization agent for amine detection.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
• H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P264, P270, P273, P301+P317, P330, P391, and P501

Hazard Classes and Categories

• Acute Tox. 4 (15.3%)
• Skin Irrit. 2 (84.7%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (70.8%)
• Aquatic Chronic 3 (15.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.