Description

1-Chloro-2-propanol (CAS No. 127-00-4) is a versatile chlorinated alcohol with the molecular formula C₃H₇ClO and IUPAC name 1-chloropropan-2-ol. This clear to pale yellow liquid is widely used in organic synthesis, pharmaceutical intermediates, and industrial applications due to its reactive hydroxyl and chloro functional groups. It exhibits a boiling point of approximately 126-127°C and a density of 1.113 g/cm³ at 20°C. Suitable for laboratory and bulk-scale use, our high-purity grade (≥98%) ensures consistent performance in nucleophilic substitution reactions, esterifications, and as a precursor for epoxides. Packaged in amber glass bottles or chemical-resistant drums to ensure stability. Handle with proper PPE due to potential skin/eye irritation.

Properties

• CAS Number: 127-00-4
• Complexity: 22.9
• IUPAC Name: 1-chloropropan-2-ol
• InChI: InChI=1S/C3H7ClO/c1-3(5)2-4/h3,5H,2H2,1H3
• InChI Key: YYTSGNJTASLUOY-UHFFFAOYSA-N
• Exact Mass: 94.0185425
• Molecular Formula: C3H7ClO
• Molecular Weight: 94.54
• SMILES: CC(CCl)O
• Topological: 20.2
• Monoisotopic Mass: 94.0185425
• Physical Description: 1-chloro-2-propanol is a clear colorless to light amber liquid with a mild non residual odor.
• Color/Form: COLORLESS LIQUID
• Boiling Point: 259 to 261 °F at 760 mmHg
• Flash Point: 125 °F
• Solubility: greater than or equal to 100 mg/mL at 73 °F
• Density: 1.115 at 68 °F – Denser than water; will sink
• Vapor Density: 3.3 – Heavier than air; will sink
• Vapor Pressure: 4.9 mmHg at 68 °F
• Refractive Index: INDEX OF REFRACTION: 1.4392 @ 20 °C/D
• Synonyms: 1-Chloro-2-propanol, 1-Chloropropan-2-ol, 127-00-4, 2-PROPANOL, 1-CHLORO-, .alpha.-Propylene chlorohydrin, 3-chloro-2-propanol, CCRIS 4766, chloroisopropanol, HSDB 1341, UNII-ZL0FUS96WW, EINECS 204-819-6, BRN 0773653, 3-chloropropan-2-ol, CHEBI:76260, PROPYLCHLOROHYDRIN, NSC-77373, DTXSID5020285, alpha-Propylene chlorohydrin, 1Chloro2propanol, 1Chloro2hydroxypropane, 1Chloroisopropyl alcohol, secPropylene chlorohydrin, DTXCID30285, 2-PROPANOL,1-CHLORO-, (+-)-1-CHLORO-2-PROPANOL, (.+-.)-1-CHLORO-2-PROPANOL, 1-CHLORO-2-PROPANOL, (+-)-, 4-01-00-01490 (beilstein handbook reference), un2611, yytsgnjtasluoy-uhfffaoysa-n, Chloroisopropyl alcohol, Propene chlorohydrin, 1-Chloroisopropyl alcohol, sec-Propylene chlorohydrin, 1-Chloro-2-hydroxypropane, NSC 77373, EINECS 268-361-9, ZL0FUS96WW, 1-Chloro-2-propanol, technical grade (~75% 1-chloro-2-propanol; ~25% 2-chloro-1-propanol), (S)-1-chloropropan-2-ol, 1-Chloro-2-propanol (70%, Technical Grade), 1-Cloro-2-propanol, technical, MFCD01862132, (+/-)-1-Chloro-2-propanol; 1-Chloro-2-hydroxypropane; 1-Chloroisopropyl alcohol; NSC 77373; sec-Propylene chlorohydrin; a-Propylene chlorohydrin, 1-chloro2-propanol, EINECS 269-076-2, EINECS 269-078-3, 1 -chloro-2-propanol, 1-Chloro-propan-2-ol, DSSTox_CID_285, DSSTox_RID_76444, DSSTox_GSID_21988, SCHEMBL65496, SCHEMBL203446, SCHEMBL533806, 1-Chloro-2-propanol, 70%, SCHEMBL1792220, SCHEMBL2474867, SCHEMBL5192685, SCHEMBL5954230, CHEMBL1361129, SCHEMBL19066548, NSC77373, Tox21_200998, BBL011446, MFCD00004530, SBB006614, STL146557, Chloropropanol, Propylene chlorohydrin, AKOS005720868, SB44665, SB83796, SEC-PROPYLENE CHLOROHYDRIN [MI], NCGC00091542-01, NCGC00091542-02, NCGC00091542-03, NCGC00258551-01, SEC-PROPYLENE CHLOROHYDRIN [HSDB], SY110717, 1-CHLORO-2-PROPANOL, (+/-)-, DB-062559, C3533, NS00024044, EN300-39011, H11611, Q161602

Application

1-Chloro-2-propanol serves as a key intermediate in the synthesis of propylene oxide and other epoxides. It is employed in pharmaceutical manufacturing for modifying drug scaffolds and in agrochemical production. Researchers also utilize it as a solvent or reagent in organic transformations, such as the preparation of glycidyl ethers.

Safety and Hazards

GHS Hazard Statements

• H226: Flammable liquid and vapor [Warning Flammable liquids]
• H301: Toxic if swallowed [Danger Acute toxicity, oral]
• H311: Toxic in contact with skin [Danger Acute toxicity, dermal]
• H331: Toxic if inhaled [Danger Acute toxicity, inhalation]
• H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]
• H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]
• H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
• H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P203, P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P270, P271, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P316, P318, P319, P321, P330, P361+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Acute Tox. 3 (61.3%)
• Acute Tox. 4 (37%)
• Acute Tox. 3 (60.7%)
• Skin Irrit. 2 (39.9%)
• Eye Dam. 1 (60.1%)
• Eye Irrit. 2A (39.9%)
• Acute Tox. 3 (61.3%)
• Acute Tox. 4 (36.4%)
• STOT SE 3 (39.3%)
• STOT SE 3 (60.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.