Description

2-Amino-3-bromo-6-methylpyridine (CAS No. 126325-46-0) is a high-purity brominated pyridine derivative with the molecular formula C₆H₇BrN₂. This heterocyclic compound, also known by its IUPAC name 3-bromo-6-methylpyridin-2-amine, is a versatile building block in organic synthesis and pharmaceutical research. The presence of both amino and bromo functional groups on the pyridine ring makes it a valuable intermediate for nucleophilic substitution reactions, cross-coupling reactions (such as Suzuki or Buchwald-Hartwig), and other functional group transformations. Our product is rigorously tested to ensure ≥95% purity (HPLC) and is supplied as a crystalline solid with excellent batch-to-batch consistency. Proper storage at 2-8°C under inert atmosphere is recommended to maintain stability. This chemical is intended for research purposes only and is not for drug, household, or other unauthorized uses.

Properties

• CAS Number: 126325-46-0
• Complexity: 97.1
• IUPAC Name: 3-bromo-6-methyl-pyridin-2-amine
• InChI: InChI=1S/C6H7BrN2/c1-4-2-3-5(7)6(8)9-4/h2-3H,1H3,(H2,8,9)
• InChI Key: JYWWGZAAXTYNRN-UHFFFAOYSA-N
• Exact Mass: 185.97926
• Molecular Formula: C6H7BrN2
• Molecular Weight: 187.04
• SMILES: CC1=NC(=C(C=C1)Br)N
• Topological: 38.9
• Monoisotopic Mass: 185.97926
• Synonyms: 2-Amino-3-bromo-6-methylpyridine, 126325-46-0, DTXSID00370295, DTXCID30321331, 692-684-8, 3-bromo-6-methylpyridin-2-amine, 2-Amino-3-bromo-6-picoline, 2-Pyridinamine, 3-bromo-6-methyl-, MFCD03095215, 3-bromo-6-methyl-2-pyridylamine, 2-amino-3-bromo-6-methyl-pyridine, 6-amino-5-bromo-picoline, SCHEMBL2843454, JYWWGZAAXTYNRN-UHFFFAOYSA-N, BCP26076, CS-D0971, SBB005516, AKOS006345467, AB13584, AC-1808, PS-5787, SY022319, DB-005287, ST50405575, EN300-117390, Z1201622094, 2-Amino-3-bromo-6-picoline (2-Amino-3-bromo-6-methylpyridine), 3-Bromo-6-methylpyridin-2-amine;2-Pyridinamine, 3-bromo-6-methyl-

Application

2-Amino-3-bromo-6-methylpyridine serves as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of kinase inhibitors and other bioactive molecules. Researchers utilize this compound in palladium-catalyzed cross-coupling reactions to create more complex heterocyclic systems. It’s also valuable in material science for constructing nitrogen-containing conjugated systems. The bromo substituent allows for further functionalization, while the amino group can participate in condensation reactions or serve as a directing group in metal-catalyzed transformations.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (50%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (50%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (50%)
• Eye Irrit. 2 (50%)
• Acute Tox. 4 (50%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.