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Atomfair 5-Bromo-3-fluoro-2-methoxypyridine C6H5BrFNO CAS 124432-70-8

5-Bromo-3-fluoro-2-methoxypyridine (CAS No. 124432-70-8) is a high-purity halogenated pyridine derivative with the molecular formula C6H5BrFNO . This compound is a valuable building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring bromine and fluorine substituents on a methoxy-pyridine scaffold, enables versatile reactivity for cross-coupling reactions, nucleophilic substitutions, and other functionalizations. The product is supplied as a crystalline solid with ≥95% purity (HPLC) and is rigorously tested for quality assurance. Ideal for medicinal chemistry, material science, and ligand design applications. Store under inert conditions at 2-8°C to ensure long-term stability.

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Description

5-Bromo-3-fluoro-2-methoxypyridine (CAS No. 124432-70-8) is a high-purity halogenated pyridine derivative with the molecular formula C6H5BrFNO. This compound is a valuable building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring bromine and fluorine substituents on a methoxy-pyridine scaffold, enables versatile reactivity for cross-coupling reactions, nucleophilic substitutions, and other functionalizations. The product is supplied as a crystalline solid with ≥95% purity (HPLC) and is rigorously tested for quality assurance. Ideal for medicinal chemistry, material science, and ligand design applications. Store under inert conditions at 2-8°C to ensure long-term stability.

Properties

  • CAS Number: 124432-70-8
  • Complexity: 114
  • IUPAC Name: 5-bromo-3-fluoro-2-methoxy-pyridine
  • InChI: InChI=1S/C6H5BrFNO/c1-10-6-5(8)2-4(7)3-9-6/h2-3H,1H3
  • InChI Key: DEBFRAAJISQBIE-UHFFFAOYSA-N
  • Exact Mass: 204.95385
  • Molecular Formula: C6H5BrFNO
  • Molecular Weight: 206.01
  • SMILES: COC1=C(C=C(C=N1)Br)F
  • Topological: 22.1
  • Monoisotopic Mass: 204.95385
  • Synonyms: 5-BROMO-3-FLUORO-2-METHOXYPYRIDINE, 124432-70-8, DTXSID90564545, DTXCID00515321, 2-Methoxy-3-fluoro-5-bromopyridine, Pyridine, 5-bromo-3-fluoro-2-methoxy-, 5-Bromo-3-fluoro-2-methoxy-pyridine, MFCD04112553, SCHEMBL322917, SCHEMBL16714045, DEBFRAAJISQBIE-UHFFFAOYSA-N, BBL102741, STL556547, AKOS015834220, AB17621, CS-W000809, GS-6443, SY022296, DB-024952

Application

5-Bromo-3-fluoro-2-methoxypyridine serves as a key intermediate in the synthesis of bioactive molecules, including kinase inhibitors and antimicrobial agents. Its orthogonal reactivity allows selective modification of the bromine or fluorine positions for structure-activity relationship (SAR) studies. The compound is frequently employed in Suzuki-Miyaura and Buchwald-Hartwig couplings to construct complex heterocyclic systems. Researchers also utilize it as a directing group in C-H activation chemistry.

Safety and Hazards

GHS Hazard Statements

  • H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (100%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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