Description

3-(Aminomethyl)-4-fluorophenol (CAS No. 1243414-16-5) is a high-purity fluorinated phenolic compound with the molecular formula C₇H₈FNO. This specialized chemical features both an aminomethyl group and a fluorine substituent on its aromatic ring, making it a valuable intermediate for pharmaceutical synthesis, agrochemical development, and advanced material science applications. The compound is supplied as a crystalline solid with ≥95% purity (HPLC) and is rigorously tested for consistency in quality, moisture content, and residual solvents. Ideal for researchers in medicinal chemistry, its unique structure enables participation in nucleophilic substitution reactions, reductive amination, and cross-coupling protocols. Store under inert atmosphere at 2-8°C to ensure long-term stability.

Properties

• CAS Number: 1243414-16-5
• Complexity: 110
• IUPAC Name: 3-(aminomethyl)-4-fluoro-phenol
• InChI: InChI=1S/C7H8FNO/c8-7-2-1-6(10)3-5(7)4-9/h1-3,10H,4,9H2
• InChI Key: SXPUYUKLYFBBLR-UHFFFAOYSA-N
• Exact Mass: 141.058992041
• Molecular Formula: C7H8FNO
• Molecular Weight: 141.14
• SMILES: C1=CC(=C(C=C1O)CN)F
• Topological: 46.3
• Monoisotopic Mass: 141.058992041
• Synonyms: 3-(AMINOMETHYL)-4-FLUOROPHENOL, 1243414-16-5, 2-FLUORO-5-HYDROXYBENZYLAMINE, SCHEMBL24675906, SCHEMBL28745256, MB12208, EN300-2966706

Application

3-(Aminomethyl)-4-fluorophenol serves as a key building block in the synthesis of fluorinated drug candidates, particularly for CNS-targeting therapeutics due to its blood-brain barrier permeability-enhancing properties. It is utilized in the development of PET radiotracers for neuroimaging, where the fluorine-19 isotope allows for ¹⁸F labeling. The compound’s phenolic hydroxyl and benzylamine groups also facilitate its use in polymer modification and chelating agent synthesis.

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