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Atomfair 1-Ethoxy-2,3-Difluorobenzene C8H8F2O CAS 121219-07-6

1-Ethoxy-2,3-Difluorobenzene (CAS No. 121219-07-6) is a high-purity fluorinated aromatic compound with the molecular formula C8H8F2O. This specialized chemical is widely used in pharmaceutical synthesis, agrochemical development, and advanced material research due to its unique reactivity and stability. It serves as a versatile intermediate for introducing fluorine-containing motifs into complex molecules, enhancing their biological activity or physicochemical properties. Our product is rigorously tested to ensure ≥98% purity (GC), making it ideal for sensitive applications in medicinal chemistry and catalysis. Available in sealed glass vials under inert atmosphere to guarantee shelf stability and prevent degradation. Key Features: High chemical purity (≥98% by…

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Description

1-Ethoxy-2,3-Difluorobenzene (CAS No. 121219-07-6) is a high-purity fluorinated aromatic compound with the molecular formula C8H8F2O. This specialized chemical is widely used in pharmaceutical synthesis, agrochemical development, and advanced material research due to its unique reactivity and stability. It serves as a versatile intermediate for introducing fluorine-containing motifs into complex molecules, enhancing their biological activity or physicochemical properties. Our product is rigorously tested to ensure ≥98% purity (GC), making it ideal for sensitive applications in medicinal chemistry and catalysis. Available in sealed glass vials under inert atmosphere to guarantee shelf stability and prevent degradation.

Key Features:

  • High chemical purity (≥98% by GC)
  • Stable under inert conditions
  • Low moisture content (<0.1% by Karl Fischer)
  • Compatible with Grignard reactions, cross-coupling, and nucleophilic substitutions

Properties

  • CAS Number: 121219-07-6
  • Complexity: 119
  • IUPAC Name: 1-ethoxy-2,3-difluoro-benzene
  • InChI: InChI=1S/C8H8F2O/c1-2-11-7-5-3-4-6(9)8(7)10/h3-5H,2H2,1H3
  • InChI Key: AVOGLGBKOFOSBN-UHFFFAOYSA-N
  • Exact Mass: 158.05432120
  • Molecular Formula: C8H8F2O
  • Molecular Weight: 158.14
  • SMILES: CCOC1=C(C(=CC=C1)F)F
  • Topological: 9.2
  • Monoisotopic Mass: 158.05432120
  • Synonyms: 121219-07-6, 1-Ethoxy-2,3-Difluorobenzene, DTXSID40382357, EC 441-000-4, DTXCID20333382, 441-000-4, 2,3-Difluoroethoxybenzene, 2,3-Difluorophenetole, Benzene, 1-ethoxy-2,3-difluoro-, 1-ethoxy-2,3-difluoro-benzene, MFCD07368737, 3-ethoxy-1,2-difluorobenzene, 2,3-DIFLUORO-ETHOXYBENZENE, ethoxy-2,3-difluorobenzene, SCHEMBL455887, 4-ethoxy-2,3-difluorobenzene, SCHEMBL1003999, SCHEMBL1242347, SCHEMBL1546317, SCHEMBL1547745, SCHEMBL15063808, BCP27500, SBB087285, AKOS005762861, CS-W010901, PS-8807, SB66810, AC-23885, SY016260, DB-023709, D3888, NS00023952

1-Ethoxy-2,3-Difluorobenzene is primarily employed as a building block in pharmaceutical research for developing fluorinated drug candidates, particularly in CNS and anti-inflammatory agents. Its electron-withdrawing fluorine atoms facilitate regioselective functionalization in Pd-catalyzed coupling reactions. The compound also finds use in liquid crystal material synthesis and as a precursor for specialty polymers with enhanced thermal stability. Researchers value its ability to modulate lipophilicity and metabolic stability in bioactive molecules.

Safety and Hazards

GHS Hazard Statements

  • H302: Harmful if swallowed [Warning Acute toxicity, oral]
  • H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

  • P264, P270, P273, P301+P317, P330, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (100%)
  • Aquatic Chronic 3 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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