Description
6-Methoxy-5-(trifluoromethyl)pyridin-3-amine (CAS No. 1211584-76-7) is a high-purity fluorinated pyridine derivative with the molecular formula C7H7F3N2O. This compound features a methoxy group at the 6-position and a trifluoromethyl group at the 5-position of the pyridine ring, along with an amine group at the 3-position, making it a versatile intermediate for pharmaceutical and agrochemical synthesis. With a molecular weight of 192.14 g/mol, it is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC). Ideal for research applications, this compound is stored under inert conditions to ensure stability and longevity. Suitable for use in Suzuki couplings, nucleophilic substitutions, and as a building block for bioactive molecules.
Properties
- CAS Number: 1211584-76-7
- Complexity: 174
- IUPAC Name: 6-methoxy-5-(trifluoromethyl)pyridin-3-amine
- InChI: InChI=1S/C7H7F3N2O/c1-13-6-5(7(8,9)10)2-4(11)3-12-6/h2-3H,11H2,1H3
- InChI Key: AHFNQSHZCUHVFS-UHFFFAOYSA-N
- Exact Mass: 192.05104734
- Molecular Formula: C7H7F3N2O
- Molecular Weight: 192.14
- SMILES: COC1=C(C=C(C=N1)N)C(F)(F)F
- Topological: 48.1
- Monoisotopic Mass: 192.05104734
- Synonyms: 1211584-76-7, 6-METHOXY-5-(TRIFLUOROMETHYL)PYRIDIN-3-AMINE, 5-AMINO-2-METHOXY-3-(TRIFLUOROMETHYL)PYRIDINE, MFCD17168449, SCHEMBL116558, AKOS022187325, AB71712, CS-W022508, DS-8703, SY014645, EN300-1295625, 5-(TRIFLUOROMETHYL)-6-METHOXYPYRIDIN-3-AMINE
6-Methoxy-5-(trifluoromethyl)pyridin-3-amine is a key intermediate in medicinal chemistry, particularly for the synthesis of trifluoromethyl-substituted heterocycles. It is used in the development of kinase inhibitors, antiviral agents, and agrochemicals due to its electron-withdrawing trifluoromethyl group. Researchers employ this compound in cross-coupling reactions to create complex pharmacophores. Its stability and reactivity make it suitable for high-throughput screening and combinatorial chemistry.
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