Description

1,5,7,8-Tetrahydro-2H-spiro[quinoline-6,2′-[1,3]dioxolan]-2-one (CAS No. 120686-08-0) is a high-purity spirocyclic compound with the molecular formula C₁₁H₁₃NO₃. This structurally unique molecule features a fused quinoline and dioxolane ring system, making it a valuable intermediate in organic synthesis and medicinal chemistry research. With a molecular weight of 207.23 g/mol, this compound is supplied as a fine white to off-white crystalline powder with ≥95% purity (HPLC). It is soluble in common organic solvents such as DMSO, methanol, and dichloromethane, but exhibits limited solubility in water. Store under inert conditions at 2-8°C to maintain stability. This product is ideal for researchers investigating heterocyclic compounds, spirocyclic architectures, or novel pharmacophores.

Properties

• CAS Number: 120686-08-0
• Complexity: 364
• IUPAC Name: spiro[1,3-dioxolane-2,6′-1,5,7,8-tetrahydroquinoline]-2′-one
• InChI: InChI=1S/C11H13NO3/c13-10-2-1-8-7-11(14-5-6-15-11)4-3-9(8)12-10/h1-2H,3-7H2,(H,12,13)
• InChI Key: LRJILKSBZWGQKL-UHFFFAOYSA-N
• Exact Mass: 207.08954328
• Molecular Formula: C11H13NO3
• Molecular Weight: 207.23
• SMILES: C1CC2(CC3=C1NC(=O)C=C3)OCCO2
• Topological: 47.6
• Monoisotopic Mass: 207.08954328
• Synonyms: 120686-08-0, 1,5,7,8-Tetrahydro-2H-spiro[quinoline-6,2′-[1,3]dioxolan]-2-one, Spiro[1,3-dioxolane-2,6′(2’H)-quinolin]-2′-one, 1′,5′,7′,8′-tetrahydro-, Spiro[1,3-dioxolane-2,6′-1,5,7,8-tetrahydroquinoline]-2′-one, MFCD17676260, 7′,8′-Dihydro-1’H-spiro[[1,3]dioxolane-2,6′-quinolin]-2′(5’H)-one, 2′,5′,7′,8′-tetrahydro-1’H-spiro[1,3-dioxolane-2,6′-quinolin]-2′-one, Spiro[1,3-dioxolane-2,6/'(2/’H)-quinolin]-2/’-one, 1/’,5/’,7/’,8/’-tetrahydro-, SCHEMBL4121408, SCHEMBL16800667, AKOS015898936, AS-72808, SY280188, CS-0059975, W18026, 7”,8”-Dihydro-1”H-spiro[[1,3]dioxolane-2,6”-quinolin]-2”(5”H)-one, 7 inverted exclamation mark ,8 inverted exclamation mark -Dihydro-1 inverted exclamation mark H-spiro[[1,3]dioxolane-2,6 inverted exclamation mark -quinolin]-2 inverted exclamation mark (5 inverted exclamation mark H)-one

Application

This spirocyclic quinoline derivative serves as a versatile building block in pharmaceutical research, particularly for the development of novel central nervous system (CNS) active compounds. Researchers utilize it as a key intermediate in the synthesis of potential neuroprotective agents and receptor modulators. The unique spirocyclic structure makes it valuable for studying conformational restriction effects in medicinal chemistry programs.

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