Description

Triethyl(trifluoromethyl)silane (CAS No. 120120-26-5) is a highly versatile organosilicon compound with the molecular formula C₇H₁₅F₃Si. This reagent is widely recognized for its utility in organic synthesis, particularly as a nucleophilic trifluoromethylating agent. Its unique structure, featuring a trifluoromethyl group bonded to a silicon center, enables efficient transfer of the -CF₃ moiety to electrophilic substrates under mild conditions. The compound is a clear, colorless to pale yellow liquid with excellent solubility in common organic solvents such as THF, DCM, and ether. With a purity of ≥95% (GC), it is ideal for applications in pharmaceuticals, agrochemicals, and advanced material science. Proper storage under inert atmosphere (e.g., argon or nitrogen) at 2-8°C ensures long-term stability.

Properties

• CAS Number: 120120-26-5
• Complexity: 107
• IUPAC Name: triethyl(trifluoromethyl)silane
• InChI: InChI=1S/C7H15F3Si/c1-4-11(5-2,6-3)7(8,9)10/h4-6H2,1-3H3
• InChI Key: ZHSKFONQCREGOG-UHFFFAOYSA-N
• Exact Mass: 184.08951150
• Molecular Formula: C7H15F3Si
• Molecular Weight: 184.27
• SMILES: CC[Si](CC)(CC)C(F)(F)F
• Monoisotopic Mass: 184.08951150
• Synonyms: Triethyl(trifluoromethyl)silane, 120120-26-5, DTXSID60400825, DTXCID00351680, 628-487-0, Silane, triethyl(trifluoromethyl)-, trifluoromethyltriethylsilane, Trifluoromethyl triethyl silane, MFCD00192520, (Trifluoromethyl)triethylsilane, (Triethylsilyl)trifluoromethane, TESCF3, triethyltrifloromethylsilane, trifluromethyltriethylsilane, triethyltrifluoromethylsilane, C7H15F3Si, SCHEMBL105887, Triethyl(trifluoromethyl)silane, 98%, AKOS015838472, FS-4959, s17673, SY052955, DB-299329, T2764, T71629, Triethyl(trifluoromethyl)silane, purum, >=98.0% (GC), (Trifluoromethyl)triethylsilane, Triethylsilyl trifluoromethane

Application

Triethyl(trifluoromethyl)silane is extensively used as a trifluoromethyl source in organic synthesis, enabling the introduction of -CF₃ groups into aromatic and aliphatic systems. It is particularly valuable in nucleophilic trifluoromethylation reactions for pharmaceuticals and agrochemical intermediates. The compound also serves as a key reagent in the synthesis of fluorinated polymers and specialty materials. Its mild reaction conditions and high selectivity make it a preferred choice for researchers developing novel fluorinated compounds.

Safety and Hazards

GHS Hazard Statements

• H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (100%)

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