Description

4-Phenylpyrrolidone-2 (CAS No. 1198-97-6) is a high-purity organic compound with the molecular formula C₁₀H₁₁NO. This heterocyclic lactam, also known as 4-phenylpyrrolidin-2-one, is a valuable building block in pharmaceutical and chemical research. Its unique structure, featuring a phenyl group attached to the pyrrolidone ring, makes it an essential intermediate for synthesizing bioactive molecules, agrochemicals, and specialty polymers.

Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a white to off-white crystalline powder. It is soluble in common organic solvents such as DMSO, ethanol, and chloroform, facilitating easy integration into reaction schemes. Ideal for medicinal chemistry, this compound is often employed in the development of CNS-active agents, nootropics, and other pharmacologically relevant scaffolds.

Packaged under inert gas to prevent degradation, each batch comes with comprehensive analytical documentation, including NMR, HPLC, and MS data. Store in a cool, dry place at 2-8°C for optimal stability.

Properties

• CAS Number: 1198-97-6
• Complexity: 173
• IUPAC Name: 4-phenylpyrrolidin-2-one
• InChI: InChI=1S/C10H11NO/c12-10-6-9(7-11-10)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,11,12)
• InChI Key: HOJZEMQCQRPLQQ-UHFFFAOYSA-N
• Exact Mass: 161.084063974
• Molecular Formula: C10H11NO
• Molecular Weight: 161.20
• SMILES: C1C(CNC1=O)C2=CC=CC=C2
• Topological: 29.1
• Monoisotopic Mass: 161.084063974
• Solubility: >24.2 [ug/mL]
• Synonyms: 1198-97-6, 4-Phenyl-2-pyrrolidinone, 4-Phenylpyrrolidone-2, hojzemqcqrplqq-uhfffaoysa-n, 4-Phenyl-2-pyrrolidone, 4-phenylpyrrolidin-2-one, 2-Pyrrolidinone, 4-phenyl-, Phenylpyrrolidone, 4-Phenyl-pyrrolidin-2-one, MFCD01687226, 3-phenyl-3,4-dihydro-2H-pyrrol-5-ol, CHEMBL286419, MFCD22573804, 4-Phenyl-2-pyrrolidinone; 4-Phenyl-2-pyrrolidone; ss-Phenyl-?-aminobutyric Acid Lactam, ChemDiv2_001857, MLS000762405, SCHEMBL531338, F2147-0209, SCHEMBL3947051, SCHEMBL8347265, (S)-4-Phenyl-2-pyrrolidinone, SCHEMBL21590315, 4-PHENYL-2-PYROLLIDINONE, DTXSID90923118, HMS1374E09, HMS2800K04, BCP05253, MCA62445, BDBM50017106, STK006864, STL191081, AKOS001683714, AKOS016050334, AKOS016402939, AB09758, CS-W018637, FP33249, FS-3278, HY-W017851, RAC-4-PHENYL-PYRROLIDIN-2-ONE, SB46210, SB46222, NCGC00246500-01, PD131004, SMR000437921, SY031841, SY269206, DB-083274, P2727, ST45026099, EN300-60705, Z954601980

Application

4-Phenylpyrrolidone-2 serves as a key intermediate in the synthesis of neuroactive compounds, particularly those targeting GABAergic and dopaminergic systems. Researchers utilize it to develop novel pyrrolidone derivatives with potential nootropic or anticonvulsant properties. Its rigid scaffold is also valuable in materials science for creating heat-resistant polymers. Additionally, this compound finds use in asymmetric catalysis as a chiral auxiliary.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.