Description

5-Chloro-7-nitro-1H-indole (CAS: 1197181-29-5) is a high-purity heterocyclic organic compound with the molecular formula C₈H₅ClN₂O₂. This indole derivative features a chloro substituent at the 5-position and a nitro group at the 7-position, making it a valuable intermediate in medicinal chemistry and pharmaceutical research. Its structural properties enable versatile applications in drug discovery, particularly in the synthesis of bioactive molecules targeting neurological and oncological pathways. Suitable for researchers and scientists, this product is rigorously tested for purity (>98% by HPLC) and stability, ensuring reliable performance in synthetic workflows. Packaged under inert conditions to prevent degradation, it is ideal for laboratory-scale reactions, high-throughput screening, and lead optimization studies.

Properties

• CAS Number: 1197181-29-5
• Complexity: 219
• IUPAC Name: 5-chloro-7-nitro-1H-indole
• InChI: InChI=1S/C8H5ClN2O2/c9-6-3-5-1-2-10-8(5)7(4-6)11(12)13/h1-4,10H
• InChI Key: FNZMFDOFIZJRNY-UHFFFAOYSA-N
• Exact Mass: 196.0039551
• Molecular Formula: C8H5ClN2O2
• Molecular Weight: 196.59
• SMILES: C1=CNC2=C(C=C(C=C21)Cl)[N+](=O)[O-]
• Topological: 61.6
• Monoisotopic Mass: 196.0039551
• Synonyms: 5-Chloro-7-nitro-1H-indole, 1197181-29-5, 1H-Indole, 5-chloro-7-nitro-, MFCD20923231, 5-Chloro-7-nitroindole, AKOS025405114, DS-8981, SB15301, DA-37456, SY099492, CS-0042994, EN300-338276, I11383

5-Chloro-7-nitro-1H-indole is widely used as a key building block in the synthesis of indole-based pharmaceuticals and agrochemicals. Its reactive nitro and chloro groups facilitate functionalization for the development of kinase inhibitors and serotonin receptor modulators. Researchers leverage this compound in cross-coupling reactions and heterocyclic expansions to explore novel therapeutic agents. It is also employed in fluorescence labeling and as a precursor for dyes or sensors due to its electron-withdrawing properties.

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