Description

2-Chloropyridine (CAS No. 109-09-1) is a versatile heterocyclic organic compound with the molecular formula C₅H₄ClN. This clear to pale yellow liquid is widely used as a key intermediate in pharmaceutical synthesis, agrochemical production, and specialty chemical manufacturing. Its reactive chlorine atom at the 2-position makes it an excellent building block for nucleophilic substitution reactions, metal-catalyzed cross-couplings, and other transformations. With a purity of ≥99%, our high-quality 2-Chloropyridine is rigorously tested by GC analysis to ensure consistency for research and industrial applications. Proper handling is essential as it is classified as UN2822 (Poison) with associated hazards.

Available in convenient packaging options from grams to bulk quantities, this compound is stored under inert atmosphere to maintain stability. Technical data sheets with full safety information (SDS), handling procedures, and regulatory compliance documentation are provided with every order. Our product meets the stringent requirements of pharmaceutical GMP applications when specified.

Properties

• CAS Number: 109-09-1
• Complexity: 56
• IUPAC Name: 2-chloropyridine
• InChI: InChI=1S/C5H4ClN/c6-5-3-1-2-4-7-5/h1-4H
• InChI Key: OKDGRDCXVWSXDC-UHFFFAOYSA-N
• LogP: log Kow = 1.22
• Exact Mass: 113.0032268
• Molecular Formula: C5H4ClN
• Molecular Weight: 113.54
• SMILES: C1=CC=NC(=C1)Cl
• Topological: 12.9
• Monoisotopic Mass: 113.0032268
• Physical Description: 2-chloropyridine appears as a colorless oily liquid. Toxic by ingestion and/or skin absorption. Used to make other chemicals.
• Color/Form: Oil
• Boiling Point: 170 °C
• Flash Point: 68 °C – closed cup
• Solubility: In water, 2.00X10+4 mg/L t 25 °C
• Density: 1.205 g/cu cm at 15 °C
• Vapor Pressure: 2.18 [mmHg]
• Stability/Shelf Life: Stable under recommended storage conditions.
• Refractive Index: Index of refraction: 1.5320 at 20 °C
• Dissociation Constants: pKa = 0.49
• Synonyms: 2-CHLOROPYRIDINE, o-Chloropyridine, Pyridine, 2-chloro-, alpha-Chloropyridine, .alpha.-Chloropyridine, CCRIS 1724, CHEBI:39174, UNII-8HMD45AYEJ, 8HMD45AYEJ, NSC 4649, EINECS 203-646-3, UN2822, DTXSID8024810, AI3-19231, NSC-4649, CHLOROPYRIDINE, 2-, DTXCID304810, HSDB 8442, EC 203-646-3, UN 2822, oChloropyridine, alphaChloropyridine, Pyridine, 2chloro, ORTHO-CHLOROPYRIDINE, 203-646-3, inchi=1/c5h4cln/c6-5-3-1-2-4-7-5/h1-4, okdgrdcxvwsxdc-uhfffaoysa-n, 109-09-1, 2-chloro-pyridine, Pyridine, chloro-, 2-Chloropyridine-13C5, MFCD00006228, 2-Chloro pyridine, CAS-109-09-1, chloro-pyridine, 2-chloropyridin, 2-chlorpyridine, a-chloropyridine, 2-Chloropyridine; NSC 4649; o-Chloropyridine; alpha-Chloropyridine, 2chloro-pyridine, 2-chloranylpyridine, 2-Chloropyridine, 99%, WLN: T6NJ BG, SCHEMBL16637, SCHEMBL27737, SCHEMBL59532, SCHEMBL73686, MLS001065616, SCHEMBL290421, CHEMBL509579, SCHEMBL1710997, SCHEMBL1711042, SCHEMBL1711128, SCHEMBL5592500, SCHEMBL11389784, SCHEMBL15051615, NSC4649, HMS3039I07, EDC83557, EINECS 270-187-3, Tox21_202283, Tox21_303307, BBL027569, BDBM50622780, SBB079180, STL298559, AKOS000119192, FC00155, PS-6209, 2-Chloropyridine [UN2822] [Poison], NCGC00091425-01, NCGC00091425-02, NCGC00257172-01, NCGC00259832-01, SMR000568486, DB-015948, NS00010831, EN300-18341, A801967, Q209364, F0001-0194

2-Chloropyridine serves as a crucial intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral and antihypertensive drugs. It is extensively used in palladium-catalyzed cross-coupling reactions (Suzuki, Stille) to create bipyridine ligands and other heterocyclic systems. In agrochemical production, it functions as a precursor for insecticides and herbicides. The compound also finds application in material science as a building block for liquid crystals and conductive polymers. Researchers value its versatility in medicinal chemistry for structure-activity relationship studies.

Safety and Hazards

GHS Hazard Statements

• H227: Combustible liquid [Warning Flammable liquids]
• H302: Harmful if swallowed [Warning Acute toxicity, oral]
• H310: Fatal in contact with skin [Danger Acute toxicity, dermal]
• H315: Causes skin irritation [Warning Skin corrosion/irritation]
• H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H330: Fatal if inhaled [Danger Acute toxicity, inhalation]
• H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
• H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
• H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P210, P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P284, P301+P317, P302+P352, P304+P340, P305+P354+P338, P316, P317, P319, P320, P321, P330, P332+P317, P361+P364, P362+P364, P370+P378, P391, P403, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (67%)
• Acute Tox. 4 (33%)
• Acute Tox. 2 (96.9%)
• Skin Irrit. 2 (94.8%)
• Eye Dam. 1 (37.1%)
• Eye Irrit. 2A (58.8%)
• Acute Tox. 2 (42.3%)
• Acute Tox. 3 (56.7%)
• STOT SE 3 (47.4%)
• STOT RE 2 (33%)
• Aquatic Acute 1 (51.5%)
• Aquatic Chronic 1 (46.4%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.