Description

8-Quinolinyl trifluoromethanesulfonate (CAS No. 108530-08-1) is a high-purity organic compound with the molecular formula C₁₀H₆F₃NO₃S. This specialized reagent, also known as quinolin-8-yl trifluoromethanesulfonate or 8-Quinolinyl triflate, is widely used in synthetic organic chemistry and pharmaceutical research. The compound features a quinoline backbone functionalized with a reactive trifluoromethanesulfonate (triflate) group, making it an excellent intermediate for nucleophilic substitution reactions, cross-coupling reactions, and as a precursor for more complex heterocyclic systems. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied in sealed containers under inert atmosphere to guarantee stability. Ideal for researchers developing novel catalysts, ligands, or bioactive molecules in medicinal chemistry.

Properties

• CAS Number: 108530-08-1
• Complexity: 390
• IUPAC Name: 8-quinolyl trifluoromethanesulfonate
• InChI: InChI=1S/C10H6F3NO3S/c11-10(12,13)18(15,16)17-8-5-1-3-7-4-2-6-14-9(7)8/h1-6H
• InChI Key: YUWOECMFUBVGSE-UHFFFAOYSA-N
• Exact Mass: 277.00204871
• Molecular Formula: C10H6F3NO3S
• Molecular Weight: 277.22
• SMILES: C1=CC2=C(C(=C1)OS(=O)(=O)C(F)(F)F)N=CC=C2
• Topological: 64.6
• Monoisotopic Mass: 277.00204871
• Synonyms: 8-Quinolinyl trifluoromethanesulfonate, 622-900-8, quinolin-8-yl trifluoromethanesulfonate, 108530-08-1, 8-Quinolinyl triflate, 8-QUINOLINYLTRIFLATE, 8-Quinolyl triflate, SCHEMBL249779, DTXSID90394763, 8-trifluoromethanesulfonyloxyquinoline, MFCD00274222, STL257102, AKOS015993229, 8-quinolinyl trifluoromethane-sulphonate, quinolin-8-yl trifluoro-methanesulfonate, CS-0335450, H39094, 6Y-0201

Application

8-Quinolinyl trifluoromethanesulfonate serves as a versatile building block in organic synthesis, particularly in palladium-catalyzed cross-coupling reactions for constructing complex heteroaromatic systems. The triflate group’s excellent leaving group properties enable efficient nucleophilic aromatic substitutions in pharmaceutical intermediate synthesis. Researchers utilize this compound to develop novel quinoline-based ligands for transition metal catalysis and as a precursor for fluorescent probes in biochemical studies.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.