Description

2,2-Difluorocyclopropane-1-carboxylic acid (CAS No. 107873-03-0) is a high-purity fluorinated cyclopropane derivative with the molecular formula C₄H₄F₂O₂. This compound features a cyclopropane ring substituted with two fluorine atoms at the 2-position and a carboxylic acid functional group at the 1-position, offering unique reactivity for synthetic and medicinal chemistry applications. It is supplied as a white to off-white crystalline solid with ≥95% purity (HPLC), ensuring consistency for research and industrial use. Ideal for use as a building block in pharmaceuticals, agrochemicals, and materials science, this reagent is packaged under inert conditions to maintain stability. Store in a cool, dry place away from light and moisture to preserve its integrity.

Properties

• CAS Number: 107873-03-0
• Complexity: 132
• IUPAC Name: 2,2-difluorocyclopropanecarboxylic acid
• InChI: InChI=1S/C4H4F2O2/c5-4(6)1-2(4)3(7)8/h2H,1H2,(H,7,8)
• InChI Key: KMLMOVWSQPHQME-UHFFFAOYSA-N
• Exact Mass: 122.01793569
• Molecular Formula: C4H4F2O2
• Molecular Weight: 122.07
• SMILES: C1C(C1(F)F)C(=O)O
• Topological: 37.3
• Monoisotopic Mass: 122.01793569
• Synonyms: 2,2-difluorocyclopropane-1-carboxylic Acid, 679-017-6, 2,2-Difluorocyclopropanecarboxylic acid, 107873-03-0, 2,2-difluoro-cyclopropanecarboxylic acid, MFCD04115828, C4H4F2O2, 2,2-Difluorocyclopropanecarboxylicacid, (1R)-2,2-difluorocyclopropanecarboxylic acid, CYCLOPROPANECARBOXYLIC ACID, 2,2-DIFLUORO-, MFCD30471588, MFCD30719344, (R)-2,2-Difluorocyclopropanecarboxylic Acid, (S)-2,2-difluorocyclopropane-1-carboxylic acid, (1S)(c)2,2(c)difluorocyclopropane(c)1(c)carboxylic acid, SCHEMBL301120, SCHEMBL11804551, DTXSID90382322, KMLMOVWSQPHQME-UHFFFAOYSA-N, BCP19593, CS-B1034, BBL100514, STL554308, AKOS005254595, 2.2-Difluorocyclopropanecarboxylic acid, AB20620, PB48528, SB40854, 2,2-difluoro cyclopropanecarboxylic acid, 2,2-Difluorocyclopropane carboxylic acid, 2,2-difluorocyclopropane-carboxylic acid, 2,2-difluoro-cyclopropane-carboxylic acid, AS-39483, SY027524, SY099275, SY245844, DB-121834, D5977, (rac)-2,2-difluorocyclopropanecarboxylic acid, 2,2-Difluorocyclopropanecarboxylic acid, 97%, EN300-59738, (RS)-2,2-difluoro-cyclopropanecarboxylic acid

Application

2,2-Difluorocyclopropane-1-carboxylic acid serves as a versatile intermediate in organic synthesis, particularly in the development of fluorinated bioactive molecules. Its strained cyclopropane ring and fluorine substituents make it valuable for probing steric and electronic effects in drug design. Researchers utilize this compound in the synthesis of protease inhibitors, receptor modulators, and other small-molecule therapeutics. It is also employed in material science for creating fluorinated polymers with enhanced stability. Its reactivity enables selective functionalization for tailored applications.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (39.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Precautionary Statements

• P260, P264, P264+P265, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)
• Eye Dam. 1 (39.5%)

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