Description

2-Amino-5-chloropyridine (CAS No. 1072-98-6) is a high-purity heterocyclic organic compound with the molecular formula C₅H₅ClN₂. This fine chemical is widely utilized in pharmaceutical synthesis, agrochemical research, and material science due to its versatile reactivity as a pyridine derivative. The compound features a chlorinated pyridine ring with an amine group at the 2-position, making it a valuable building block for nucleophilic substitution reactions and metal-catalyzed cross-coupling reactions. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a white to off-white crystalline powder with excellent batch-to-batch consistency. Proper storage conditions (2-8°C in a tightly sealed container under inert atmosphere) are recommended to maintain stability. Suitable for use in medicinal chemistry, ligand synthesis, and as a precursor for more complex nitrogen-containing heterocycles.

Properties

• CAS Number: 1072-98-6
• Complexity: 76.8
• IUPAC Name: 5-chloropyridin-2-amine
• InChI: InChI=1S/C5H5ClN2/c6-4-1-2-5(7)8-3-4/h1-3H,(H2,7,8)
• InChI Key: MAXBVGJEFDMHNV-UHFFFAOYSA-N
• Exact Mass: 128.0141259
• Molecular Formula: C5H5ClN2
• Molecular Weight: 128.56
• SMILES: C1=CC(=NC=C1Cl)N
• Topological: 38.9
• Monoisotopic Mass: 128.0141259
• Physical Description: Beige crystalline solid;
• Synonyms: 2-Amino-5-chloropyridine, 1072-98-6, 5-Chloro-2-pyridinamine, 5-Chloro-2-pyridylamine, EINECS 214-020-4, AI3-52448, DTXSID0073247, NSC 26283, 5Chloro2pyridylamine, 2Pyridinamine, 5chloro, DTXCID8033063, 214-020-4, inchi=1/c5h5cln2/c6-4-1-2-5(7)8-3-4/h1-3h,(h2,7,8, 5-chloropyridin-2-amine, 2-Pyridinamine, 5-chloro-, Pyridine, 2-amino-5-chloro-, 5-Chloro-2-aminopyridine, MFCD00006324, 5-chloropyridin-2-ylamine, NSC-26283, 2-amino5-chloropyridine, 2-amino-5-chloro pyridine, 5-chloro-pyridin-2-ylamine, NSC26283, 2-amino-5chloropyridine, 2-amino-5-chloropyrdine, 2-amino-5-chloropyridin, 2-amino-5-cloropyridine, 5-chloropyridine-2-amine, J8TAP6NFD4, 2-Amino-5-Chloro-pyridine, SCHEMBL77304, SCHEMBL839519, 5-chloropyridin-2(1H)-imine, SCHEMBL1428139, SCHEMBL2799371, SCHEMBL7922633, SCHEMBL8082785, SCHEMBL11548157, (5-chloro-pyridin-2-yl)-amine, 2-Amino-5-chloropyridine, 98%, BCP23345, STR00702, AB2782, SBB000059, STK398098, STL453491, AKOS000119653, AKOS025397221, AB00712, AC-2429, CCG-325545, CS-W018533, FA00128, PS-3640, BP-12769, RP-26695, SY001089, DB-014014, A0837, NS00021491, ST45255332, EN300-19819, 5-Chloro-2-pyridinamine;5-Chloropyridin-2-amine, AC-907/34116008, AG-617/02036012, AH-034/32826050, 2-Amino-5-chloropyridine, purum, >=98.0% (NT), F0001-0149, Z104475596, 2-Amino-5-chloropyridine, British Pharmacopoeia (BP) Reference Standard

Application

2-Amino-5-chloropyridine serves as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of antiviral and antibacterial agents. In agrochemical research, it is employed as a precursor for crop protection chemicals and pesticide formulations. The compound’s dual functionality makes it valuable for creating coordination complexes in catalytic systems and as a scaffold for drug discovery programs targeting kinase inhibition.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (19%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (19%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (11.1%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (14.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (19%)
• Eye Irrit. 2 (19%)
• Acute Tox. 4 (11.1%)
• STOT SE 3 (14.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.