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Atomfair 2-(Trifluoromethyl)-1,3-oxazole-4-carboxylic acid C5H2F3NO3 CAS 1060816-01-4

2-(Trifluoromethyl)-1,3-oxazole-4-carboxylic acid (CAS No. 1060816-01-4) is a high-purity heterocyclic carboxylic acid featuring a trifluoromethyl group, designed for advanced research and pharmaceutical applications. With the molecular formula C5H2F3NO3, this compound exhibits unique reactivity due to its oxazole core and electron-withdrawing trifluoromethyl substituent. It is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC), ensuring consistency for synthetic and medicinal chemistry studies. Ideal for use as a building block in the development of fluorinated bioactive molecules, agrochemicals, and materials science applications. Store in a cool, dry place under inert conditions to maintain stability.

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Description

2-(Trifluoromethyl)-1,3-oxazole-4-carboxylic acid (CAS No. 1060816-01-4) is a high-purity heterocyclic carboxylic acid featuring a trifluoromethyl group, designed for advanced research and pharmaceutical applications. With the molecular formula C5H2F3NO3, this compound exhibits unique reactivity due to its oxazole core and electron-withdrawing trifluoromethyl substituent. It is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC), ensuring consistency for synthetic and medicinal chemistry studies. Ideal for use as a building block in the development of fluorinated bioactive molecules, agrochemicals, and materials science applications. Store in a cool, dry place under inert conditions to maintain stability.

Properties

  • CAS Number: 1060816-01-4
  • Complexity: 193
  • IUPAC Name: 2-(trifluoromethyl)oxazole-4-carboxylic acid
  • InChI: InChI=1S/C5H2F3NO3/c6-5(7,8)4-9-2(1-12-4)3(10)11/h1H,(H,10,11)
  • InChI Key: MGJCQGMJTNTRSM-UHFFFAOYSA-N
  • Exact Mass: 180.99867741
  • Molecular Formula: C5H2F3NO3
  • Molecular Weight: 181.07
  • SMILES: C1=C(N=C(O1)C(F)(F)F)C(=O)O
  • Topological: 63.3
  • Monoisotopic Mass: 180.99867741
  • Synonyms: 1060816-01-4, 2-(trifluoromethyl)-1,3-oxazole-4-carboxylic acid, 854-244-5, 2-(TRIFLUOROMETHYL)OXAZOLE-4-CARBOXYLIC ACID, 2-(trifluoroMethyl)oxazole-4-carboxylicacid, MFCD13189374, SCHEMBL2481569, MGJCQGMJTNTRSM-UHFFFAOYSA-N, AKOS022706702, AB68291, AT18526, DB-133958, EN300-107467, 2-(TRIFLUOROMETHYL)-4-OXAZOLECARBOXYLIC ACID, Z1255440209

Application

2-(Trifluoromethyl)-1,3-oxazole-4-carboxylic acid serves as a versatile intermediate in the synthesis of fluorinated heterocycles, particularly in pharmaceutical research for drug candidates targeting inflammation or infectious diseases. Its trifluoromethyl group enhances metabolic stability and lipophilicity, making it valuable for optimizing pharmacokinetic properties. Researchers also utilize it in agrochemical development to create novel pesticides with improved efficacy. The oxazole ring’s rigidity and polarity further enable applications in materials science, such as designing organic semiconductors or ligands for catalysis.

Safety and Hazards

GHS Hazard Statements

  • H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (100%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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