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Atomfair Benidipine C28H31N3O6 CAS 105979-17-7

Benidipine (CAS: 105979-17-7) is a highly selective calcium channel blocker belonging to the dihydropyridine class, widely utilized in cardiovascular research and pharmacological studies. With the molecular formula C28H31N3O6, this compound exhibits potent vasodilatory effects by inhibiting L-type calcium channels, making it invaluable for hypertension and angina research. Its unique stereochemistry, featuring an (R,R)-configuration, enhances its binding affinity and duration of action. Benidipine is supplied as a high-purity analytical standard (>98%), rigorously tested via HPLC, NMR, and MS to ensure consistency for in vitro and in vivo applications. Packaged under inert conditions to guarantee stability, it is ideal for drug discovery,…

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Description

Benidipine (CAS: 105979-17-7) is a highly selective calcium channel blocker belonging to the dihydropyridine class, widely utilized in cardiovascular research and pharmacological studies. With the molecular formula C28H31N3O6, this compound exhibits potent vasodilatory effects by inhibiting L-type calcium channels, making it invaluable for hypertension and angina research. Its unique stereochemistry, featuring an (R,R)-configuration, enhances its binding affinity and duration of action. Benidipine is supplied as a high-purity analytical standard (>98%), rigorously tested via HPLC, NMR, and MS to ensure consistency for in vitro and in vivo applications. Packaged under inert conditions to guarantee stability, it is ideal for drug discovery, mechanism-of-action studies, and preclinical trials. Available in milligram to gram quantities with optional custom formulations.

Properties

  • CAS Number: 105979-17-7
  • Complexity: 933
  • IUPAC Name: O5-[(3R)-1-benzyl-3-piperidyl] O3-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • InChI: InChI=1S/C28H31N3O6/c1-18-24(27(32)36-3)26(21-11-7-12-22(15-21)31(34)35)25(19(2)29-18)28(33)37-23-13-8-14-30(17-23)16-20-9-5-4-6-10-20/h4-7,9-12,15,23,26,29H,8,13-14,16-17H2,1-3H3/t23-,26-/m1/s1
  • InChI Key: QZVNQOLPLYWLHQ-ZEQKJWHPSA-N
  • Exact Mass: 505.22128572
  • Molecular Formula: C28H31N3O6
  • Molecular Weight: 505.6
  • SMILES: CC1=C([C@H](C(=C(N1)C)C(=O)O[C@@H]2CCCN(C2)CC3=CC=CC=C3)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC
  • Topological: 114
  • Monoisotopic Mass: 505.22128572
  • Melting Point: >193ºC
  • Solubility: <1 mg/ml
  • Dissociation Constants: 7.34
  • Synonyms: Benidipine, 105979-17-7, Benidipine [INN], Benidipinum, Benidipino, Benidipinum [Latin], Benidipino [Spanish], Benidipine (INN), 4G9T91JS7E, BENIDIPINE [MI], BENIDIPINE [WHO-DD], Benidipinum (Latin), (+-)-(R*)-3-((R*)-1-Benzyl-3-piperidyl) methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate, (4R)-REL-1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID METHYL (3R)-1-(PHENYLMETHYL)-3-PIPERIDINYL ESTER, C08CA15, (+-)-2,6-DIMETHYL-4-(3-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID-3-(1-BENZYL-3-PIPERIDYL) ESTER-5-METHYL ESTER, 3-(3R)-1-benzylpiperidin-3-yl 5-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, Benidipene, 119065-60-0, 5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, (-)-Alpha Benidipine, NCGC00185768-01, UNII-4G9T91JS7E, Alpha benidipine, (-)-, K2TQS8L6NJ, SCHEMBL24516, CHEMBL2105555, CHEMBL3303980, DTXSID0022648, HY-B1448A, AKOS015895389, DB09231, MRF-0000234, NCGC00185768-03, 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester, (4R)-, PD156024, CS-0111103, NS00073186, D07509, AB01209735-01, AB01566847_01, EN300-27161348, BRD-K97181463-003-01-1, BRD-K97181463-003-02-9, Q11336997, (+/-)-(R*)-3-((R*)-1-BENZYL-3-PIPERIDYL) METHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(M-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE, (+/-)-2,6-DIMETHYL-4-(3-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID-3-(1-BENZYL-3-PIPERIDYL) ESTER-5-METHYL ESTER, (3r)-1-benzyl-3-piperidinyl methyl (4r)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridine dicarboxylate, (R)-rel-3-((R)-1-Benzylpiperidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, [R-(R*,R*)]-, 3-Methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] (4R)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate, methyl (3R)-1-(phenylmethyl)piperidin-3-yl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, rac-3-(3R)-1-benzylpiperidin-3-yl 5-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Benidipine is primarily used in cardiovascular research to study its antihypertensive and antianginal effects via L-type calcium channel blockade. It serves as a reference compound in pharmacokinetic studies due to its prolonged action and tissue penetration. Researchers also employ it to investigate vascular smooth muscle relaxation and endothelial function modulation. Suitable for cell-based assays and animal models of hypertension.

Safety and Hazards

GHS Hazard Statements

  • H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

Precautionary Statements

  • P264, P270, P301+P316, P321, P330, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

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  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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