Description

4-(Diphenylmethyl)-1-piperazineethanol (CAS No. 10527-64-7) is a high-purity organic compound with the molecular formula C₁₉H₂₄N₂O. This versatile intermediate, also known as Cetirizine alcohol, features a piperazineethanol backbone substituted with a benzhydryl group, making it valuable for pharmaceutical synthesis and research applications. With a molecular weight of 296.41 g/mol, this white to off-white crystalline powder offers excellent solubility in common organic solvents. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied with comprehensive analytical documentation including ¹H NMR, HPLC chromatograms, and mass spectrometry data. Ideal for medicinal chemistry, this building block is particularly relevant for antihistamine drug development and CNS-active compound research. Packaged under inert atmosphere in amber glass vials with PTFE-lined caps to ensure stability during storage and shipping.

Properties

• CAS Number: 10527-64-7
• Complexity: 285
• IUPAC Name: 2-(4-benzhydrylpiperazin-1-yl)ethanol
• InChI: InChI=1S/C19H24N2O/c22-16-15-20-11-13-21(14-12-20)19(17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,19,22H,11-16H2
• InChI Key: QEYZAHKHYSGDJK-UHFFFAOYSA-N
• Exact Mass: 296.188863393
• Molecular Formula: C19H24N2O
• Molecular Weight: 296.4
• SMILES: C1CN(CCN1CCO)C(C2=CC=CC=C2)C3=CC=CC=C3
• Topological: 26.7
• Monoisotopic Mass: 296.188863393
• Synonyms: 10527-64-7, Cetirizine alcohol, 4-benzhydryl-1-piperazineethanol, 1-Piperazineethanol, 4-(diphenylmethyl)-, 9AMR7XC6Q8, 4-(Diphenylmethyl)-1-piperazineethanol, 2-(4-benzhydrylpiperazin-1-yl)ethanol, 1-diphenylmethyl-4-(2-hydroxyethyl)piperazine, UNII-9AMR7XC6Q8, 2-(4-benzhydrylpiperazin-1-yl)ethan-1-ol, 2-[4-(diphenylmethyl)piperazin-1-yl]ethan-1-ol, CETIRIZINE IMPURITY 46, SCHEMBL1491229, SCHEMBL7381083, SCHEMBL8629042, CHEMBL1254795, QEYZAHKHYSGDJK-UHFFFAOYSA-N, DTXSID401283035, MFCD06742676, AKOS003588739, 2-(4-benzhydryl piperazine-1-yl)ethanol, 2-(4-benzhydryl piperazine-1-yl) ethanol, DB-337187, G87516, A1-50250

Application

4-(Diphenylmethyl)-1-piperazineethanol serves as a key intermediate in the synthesis of second-generation antihistamines, particularly cetirizine derivatives. Researchers utilize this compound in developing novel histamine H₁-receptor antagonists with reduced sedative effects. The benzhydryl-piperazine structure makes it valuable for studying structure-activity relationships in CNS-targeting pharmaceuticals. Additionally, it finds application in the preparation of zwitterionic compounds for improved blood-brain barrier penetration studies.

Safety and Hazards

GHS Hazard Statements

• H225 (20%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
• H304 (20%): May be fatal if swallowed and enters airways [Danger Aspiration hazard]
• H315 (20%): Causes skin irritation [Warning Skin corrosion/irritation]
• H336 (20%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]
• H361 (20%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
• H373 (20%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P318, P319, P321, P330, P331, P332+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (20%)
• Acute Tox. 3 (100%)
• Asp. Tox. 1 (20%)
• Skin Irrit. 2 (20%)
• STOT SE 3 (20%)
• Repr. 1B (20%)
• STOT RE 2 (20%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.