Description

2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethanol (CAS: 1040377-08-9) is a highly specialized boronate ester compound with the molecular formula C₁₁H₁₉BN₂O₃. This chemical features a pyrazole ring functionalized with a 4,4,5,5-tetramethyl-1,3,2-dioxaborolane moiety and an ethanol side chain, making it a versatile intermediate for organic synthesis and pharmaceutical research. Its unique structure enables applications in Suzuki-Miyaura cross-coupling reactions, medicinal chemistry, and as a precursor for boron-containing scaffolds. The compound is supplied as a high-purity solid with rigorous QC validation, ensuring consistency for sensitive research applications. Store under inert conditions to maintain stability.

Properties

• CAS Number: 1040377-08-9
• Complexity: 270
• IUPAC Name: 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]ethanol
• InChI: InChI=1S/C11H19BN2O3/c1-10(2)11(3,4)17-12(16-10)9-7-13-14(8-9)5-6-15/h7-8,15H,5-6H2,1-4H3
• InChI Key: QEHDAUWYRNEWBF-UHFFFAOYSA-N
• Exact Mass: 238.1488726
• Molecular Formula: C11H19BN2O3
• Molecular Weight: 238.09
• SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CN(N=C2)CCO
• Topological: 56.5
• Monoisotopic Mass: 238.1488726
• Synonyms: 1040377-08-9, 2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethanol, 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]ethanol, 2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethan-1-ol, 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE-1-ETHANOL, MFCD12033564, 1-(2-HYDROXYETHYL)-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER, 1-(HYDROXYETHYL)PYRAZOLE-4-BORONIC ACID PINACOL ESTER, 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethan-1-ol, 2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethan-1-ol, 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethanol, QEHDAUWYRNEWBF-UHFFFAOYSA-N, SCHEMBL20759, DTXSID00671779, CS-D1545, AKOS015945123, PB29947, DS-17272, SY006739, DB-059086, (1-(2-HYDROXYETHYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER, 2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]-ethanol

Application

This compound is widely used as a key intermediate in Suzuki-Miyaura cross-coupling reactions for the synthesis of biaryl compounds in pharmaceutical development. It serves as a protected boronic acid derivative for controlled functionalization in medicinal chemistry. Researchers also employ it in the design of boron-based enzyme inhibitors and PET radiotracer precursors.

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