Description

Tert-butyl 2,7-diazaspiro(3.5)nonane-7-carboxylate hydrochloride (CAS No. 1023301-84-9) is a high-purity, synthetic organic compound with the molecular formula C₁₂H₂₃ClN₂O₂. This spirocyclic amine derivative is protected with a tert-butyloxycarbonyl (Boc) group, making it a valuable intermediate in pharmaceutical research and medicinal chemistry. The hydrochloride salt form enhances its stability and solubility for synthetic applications. With a molecular weight of 262.78 g/mol, this compound is rigorously characterized by HPLC, NMR, and mass spectrometry to ensure ≥95% purity. Ideal for peptide coupling, heterocycle synthesis, and as a building block for bioactive molecules, it is supplied in sealed containers under inert atmosphere to maintain integrity. Store at 2-8°C in a dry environment.

Properties

• CAS Number: 1023301-84-9
• Complexity: 269
• IUPAC Name: tert-butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate;hydrochloride
• InChI: InChI=1S/C12H22N2O2.ClH/c1-11(2,3)16-10(15)14-6-4-12(5-7-14)8-13-9-12;/h13H,4-9H2,1-3H3;1H
• InChI Key: HVLQURGQQISYSQ-UHFFFAOYSA-N
• Exact Mass: 262.1448057
• Molecular Formula: C12H23ClN2O2
• Molecular Weight: 262.77
• SMILES: CC(C)(C)OC(=O)N1CCC2(CC1)CNC2.Cl
• Topological: 41.6
• Monoisotopic Mass: 262.1448057
• Synonyms: tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride, Tert-butyl 2,7-diazaspiro(3.5)nonane-7-carboxylate hydrochloride, 806-356-0, 1023301-84-9, 7-Boc-2,7-diaza-spiro[3.5]nonane hydrochloride, 2,7-Diazaspiro[3.5]nonane-7-carboxylic acid, 1,1-dimethylethyl ester, hydrochloride (1:1), MFCD13185086, tert-Butyl2,7-diazaspiro[3.5]nonane-7-carboxylatehydrochloride, tert-butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate;hydrochloride, tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate, HCl, 2,7-diazaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester hydrochloride, 2GRW4TT7JL, 7-Boc-2,7-diazaspiro[3.5]nonane Hydrochloride, SCHEMBL994266, DTXSID10670470, HVLQURGQQISYSQ-UHFFFAOYSA-N, CS-D0628, AKOS015844702, GS-4200, SB10180, 7-Boc-2,7-diazaspiro[3.5]nonane HCl, SY021776, DB-361609, EN300-365073, 7-(tert-butoxycarbonyl)-7-aza-2-azoniaspiro[3.5]nonane chloride, TERT-BUTYL 2,7-DIAZASPIRO[3.5]NONANE-7-CARBOXYLATE HCL, 2,7-diaza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester hydrochloride, tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate–hydrogen chloride (1/1)

Application

This Boc-protected diazaspiro compound is widely used as a key intermediate in the synthesis of pharmacologically active molecules, particularly in the development of central nervous system (CNS) drugs and enzyme inhibitors. Its spirocyclic structure contributes to conformational rigidity, enhancing binding affinity in target interactions. Researchers employ it in peptide mimetics design and as a scaffold for fragment-based drug discovery. The hydrochloride salt form facilitates handling in polar solvents during coupling reactions.

Safety and Hazards

GHS Hazard Statements

• H301 (97.6%): Toxic if swallowed [Danger Acute toxicity, oral]

Precautionary Statements

• P264, P270, P301+P316, P321, P330, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (97.6%)

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