Description

2,5-Difluoro-4-iodopyridine (CAS No. 1017793-20-2) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₂F₂IN. This compound is a versatile building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring both fluorine and iodine substituents on the pyridine ring, enables selective cross-coupling reactions such as Suzuki-Miyaura or Stille couplings. The product is supplied as a crystalline solid with ≥95% purity (HPLC) and is rigorously tested for stability and consistency. Ideal for use in medicinal chemistry, it serves as a key intermediate in the development of bioactive molecules, including kinase inhibitors and fluorinated analogs. Store under inert conditions at 2-8°C to maintain optimal stability.

Properties

• CAS Number: 1017793-20-2
• Complexity: 101
• IUPAC Name: 2,5-difluoro-4-iodo-pyridine
• InChI: InChI=1S/C5H2F2IN/c6-3-2-9-5(7)1-4(3)8/h1-2H
• InChI Key: OBVRKNZQNKGNTQ-UHFFFAOYSA-N
• Exact Mass: 240.92000
• Molecular Formula: C5H2F2IN
• Molecular Weight: 240.98
• SMILES: C1=C(C(=CN=C1F)F)I
• Topological: 12.9
• Monoisotopic Mass: 240.92000
• Synonyms: 2,5-DIFLUORO-4-IODOPYRIDINE, 1017793-20-2, DTXSID40692903, DTXCID40643652, 966-733-1, 2,5-difluoro-4-iodo-pyridine, Pyridine, 2,5-difluoro-4-iodo-, MFCD11040606, Difluoro-4-iodopyridine, SCHEMBL2016623, OBVRKNZQNKGNTQ-UHFFFAOYSA-N, BCP14926, BBL102442, STL556244, AKOS015853520, PB47990, AC-25104, DS-16884, SY030496, DB-083251, CS-0005562, P17560, EN300-7364184

Application

2,5-Difluoro-4-iodopyridine is widely employed as a precursor in palladium-catalyzed cross-coupling reactions to introduce fluorinated pyridine motifs into complex molecules. Its reactivity is leveraged in the synthesis of fluorinated pharmaceuticals, particularly those targeting CNS disorders and oncology. The compound also finds utility in material science for constructing electron-deficient aromatic systems in organic electronics. Researchers value its compatibility with modern synthetic methodologies, including late-stage functionalization.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (50%)

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