Description

N-(2-bromo-4-fluorophenyl)acetamide (CAS No. 1009-22-9) is a high-purity halogenated acetamide derivative with the molecular formula C₈H₇BrFNO. This compound features a bromo-fluorophenyl backbone coupled with an acetamide functional group, making it a valuable intermediate in organic synthesis and pharmaceutical research. Its precise molecular weight (232.05 g/mol) and well-defined structure ensure reproducibility in experimental applications. Available in crystalline or powdered form, this reagent is rigorously tested for purity (typically ≥95% by HPLC) and stability, packaged under inert conditions to prevent degradation. Ideal for researchers requiring reliable building blocks for heterocyclic chemistry, cross-coupling reactions, or medicinal chemistry studies.

Properties

• CAS Number: 1009-22-9
• Complexity: 176
• IUPAC Name: N-(2-bromo-4-fluoro-phenyl)acetamide
• InChI: InChI=1S/C8H7BrFNO/c1-5(12)11-8-3-2-6(10)4-7(8)9/h2-4H,1H3,(H,11,12)
• InChI Key: JAVSBNOXENOHEI-UHFFFAOYSA-N
• Exact Mass: 230.96950
• Molecular Formula: C8H7BrFNO
• Molecular Weight: 232.05
• SMILES: CC(=O)NC1=C(C=C(C=C1)F)Br
• Topological: 29.1
• Monoisotopic Mass: 230.96950
• Synonyms: 1009-22-9, N-(2-bromo-4-fluorophenyl)acetamide, JAVSBNOXENOHEI-UHFFFAOYSA-, DTXSID40350819, DTXCID40301886, 600-141-3, inchi=1/c8h7brfno/c1-5(12)11-8-3-2-6(10)4-7(8)9/h2-4h,1h3,(h,11,12), 2′-Bromo-4′-fluoroacetanilide, 2-Bromo-4-fluoroacetanilide, N-ACETYL 2-BROMO-4-FLUOROANILINE, Acetamide, N-(2-bromo-4-fluorophenyl)-, 2/’-Bromo-4/’-fluoroacetanilide, N-(2-Bromo-4-fluoro-phenyl)acetamide, MFCD00061118, Maybridge3_000074, EC 600-141-3, SCHEMBL422893, JAVSBNOXENOHEI-UHFFFAOYSA-N, HMS1431D08, SBB097860, AKOS002272713, FB71093, IDI1_011461, N-(2-bromo-4-fluoro-phenyl)-acetamide, AC-15660, AS-63600, DB-020626, B2721, CS-0147073, NS00010012, ST50165199, D88957, Z361888984

Application

N-(2-bromo-4-fluorophenyl)acetamide serves as a versatile synthon in the preparation of pharmacologically active compounds, particularly in Suzuki-Miyaura coupling reactions to construct biaryl scaffolds. Its bromo and fluoro substituents enable selective functionalization for drug discovery targeting kinase inhibitors or antimicrobial agents. The acetamide moiety also facilitates further derivatization via hydrolysis or condensation reactions. Researchers utilize this compound in material science for designing liquid crystals or organic semiconductors due to its planar aromatic system with halogen handles.

Safety and Hazards

GHS Hazard Statements

• H301 (86.7%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (11.1%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (86.7%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (97.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (97.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (86.7%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H335 (95.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (86.7%)
• Acute Tox. 4 (11.1%)
• Acute Tox. 3 (86.7%)
• Skin Irrit. 2 (97.8%)
• Eye Irrit. 2 (97.8%)
• Acute Tox. 3 (86.7%)
• STOT SE 3 (95.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.