Description

1-(3-Bromo-4-fluorophenyl)ethan-1-one (CAS No. 1007-15-4) is a high-purity aromatic ketone compound with the molecular formula C₈H₆BrFO. This organic intermediate features a bromo-fluorophenyl backbone and an acetyl functional group, making it a versatile building block for pharmaceutical, agrochemical, and materials science research. With a molecular weight of 217.04 g/mol, it is supplied as a crystalline solid with >98% purity (HPLC) and is rigorously tested for consistency, stability, and trace solvent residues. Ideal for Suzuki couplings, nucleophilic substitutions, and other cross-coupling reactions, this compound is packaged under inert gas to ensure long-term stability. Available in research quantities from milligrams to kilograms, with custom synthesis and bulk pricing options.

Properties

• CAS Number: 1007-15-4
• Complexity: 160
• IUPAC Name: 1-(3-bromo-4-fluoro-phenyl)ethanone
• InChI: InChI=1S/C8H6BrFO/c1-5(11)6-2-3-8(10)7(9)4-6/h2-4H,1H3
• InChI Key: SZDWTGAORQQQGY-UHFFFAOYSA-N
• Exact Mass: 215.95861
• Molecular Formula: C8H6BrFO
• Molecular Weight: 217.03
• SMILES: CC(=O)C1=CC(=C(C=C1)F)Br
• Topological: 17.1
• Monoisotopic Mass: 215.95861
• Synonyms: 1007-15-4, 1-(3-Bromo-4-fluorophenyl)ethanone, 1-(3-Bromo-4-fluorophenyl)ethan-1-one, EINECS 213-750-0, SZDWTGAORQQQGY-UHFFFAOYSA-, DTXSID50143456, DTXCID4065947, 213-750-0, inchi=1/c8h6brfo/c1-5(11)6-2-3-8(10)7(9)4-6/h2-4h,1h3, 3′-Bromo-4′-fluoroacetophenone, 3-Bromo-4-fluoroacetophenone, Ethanone, 1-(3-bromo-4-fluorophenyl)-, 3′-Bromo-4′-fluoroacetophone, MFCD00042466, 3/’-Bromo-4/’-fluoroacetophenone, 1-acetyl-3-bromo-4-fluorobenzene, 1-(3-bromo-4-fluoro-phenyl)-ethanone, SCHEMBL381027, 3-bromo-4-fluoro-acetophenone, 3-fluoroacetophenone, 3′-Bromo-4′-fluoroacetophenone, CL8652, SBB063810, AKOS001320762, AC-3001, CS-W008221, 1-(3-Bromo-4-fluorophenyl)ethanone #, 1-(4-fluoro-3-bromo-phenyl)-ethanone, 3′-Bromo-4′-fluoroacetophenone, 96%, AS-12923, SY003533, B2014, NS00042983, ST50405284, EN300-24725, Z199532232, 3 inverted exclamation mark -Bromo-4 inverted exclamation mark -fluoroacetophenone, 3 inverted exclamation marka-Bromo-4 inverted exclamation marka-fluoroacetophenone

Application

1-(3-Bromo-4-fluorophenyl)ethan-1-one serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and liquid crystal materials. Its reactive bromo and fluoro substituents enable selective functionalization for drug discovery programs targeting kinase inhibitors or CNS-active compounds. Researchers also utilize it in the development of fluorinated liquid crystals for display technologies. The compound’s stability under inert conditions makes it suitable for multi-step synthetic workflows.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.