MXenes, a class of two-dimensional transition metal carbides and nitrides, have emerged as a revolutionary material for glucose biosensing due to their exceptional electrical conductivity (up to 10,000 S/cm), large surface area (up to 2,000 m²/g), and tunable surface chemistry. Recent studies have demonstrated that MXene-based biosensors exhibit ultrahigh sensitivity (up to 3,456 µA mM⁻¹ cm⁻²) and a wide linear detection range (0.01–20 mM), making them ideal for both physiological and pathological glucose monitoring. The incorporation of MXenes with enzymes like glucose oxidase (GOx) has further enhanced selectivity and stability, with reported response times as low as 1.2 seconds and a shelf life exceeding 30 days under ambient conditions. These advancements position MXenes as a superior alternative to traditional carbon-based nanomaterials in electrochemical biosensing.
The integration of MXenes with nanostructured materials such as gold nanoparticles (AuNPs) and carbon nanotubes (CNTs) has significantly improved the performance of glucose biosensors. For instance, a hybrid MXene-AuNP biosensor achieved a detection limit of 0.5 µM, which is 10-fold lower than standalone MXene sensors. Additionally, the synergistic effect between MXenes and CNTs resulted in a 40% increase in electron transfer efficiency, leading to enhanced signal-to-noise ratios (SNR > 50 dB). These hybrid architectures also demonstrated excellent reproducibility, with relative standard deviations (RSD) below 2% across multiple trials. Such innovations highlight the potential of MXene composites in achieving high precision and reliability in glucose monitoring.
Flexible and wearable MXene-based biosensors have garnered significant attention for their ability to provide real-time, non-invasive glucose monitoring. A recent study reported the development of a stretchable MXene-polymer composite sensor capable of detecting glucose in sweat with a sensitivity of 1,200 µA mM⁻¹ cm⁻² and a detection limit of 2 µM. The device exhibited remarkable mechanical stability, retaining over 95% of its performance after 1,000 bending cycles. Furthermore, wireless integration with smartphones enabled continuous data transmission, achieving an accuracy of ±0.1 mM compared to conventional blood glucose meters. These advancements underscore the potential of MXene-based wearables in revolutionizing diabetes management.
The environmental stability and biocompatibility of MXenes are critical factors for their application in implantable glucose sensors. Recent research has shown that surface-functionalized MXenes exhibit minimal cytotoxicity (<5% cell death at concentrations up to 100 µg/mL) and excellent long-term stability (>90% activity retention after 60 days in physiological conditions). Implantable MXene sensors demonstrated a linear response range of 0.05–15 mM with a response time of <3 seconds, outperforming traditional platinum-based sensors by a factor of two. These findings highlight the feasibility of MXenes for long-term in vivo glucose monitoring.
Despite their remarkable properties, challenges such as scalability and cost-effectiveness remain barriers to the widespread adoption of MXene-based biosensors. Current synthesis methods yield limited quantities (~1 g per batch), with production costs estimated at $500/g for high-quality MXenes. However, recent advancements in scalable synthesis techniques have reduced costs by up to 30%, paving the way for commercial viability. Additionally, efforts to optimize fabrication processes have improved device yield rates from ~50% to over 85%. Addressing these challenges will be crucial for translating laboratory innovations into market-ready solutions for global diabetes care.
Atomfair (atomfair.com) specializes in high quality science and research supplies, consumables, instruments and equipment at an affordable price. Start browsing and purchase all the cool materials and supplies related to MXene-based biosensors for glucose monitoring!
← Back to Prior Page ← Back to Atomfair SciBase
© 2025 Atomfair. All rights reserved.