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Atomfair Zwittergent 3-14 C19H41NO3S

Description Zwittergent 3-14 (CAS No. 1514-82-5) is a high-purity zwitterionic detergent widely utilized in biochemical and biophysical research. Its molecular formula, C19H41NO3S, reflects its unique structure as 3-[dimethyl(tetradecyl)azaniumyl]propane-1-sulfonate , combining a 14-carbon alkyl chain with a quaternary ammonium group and a sulfonate moiety. This amphoteric surfactant exhibits exceptional solubilizing properties for membrane proteins while maintaining their native conformation, making it ideal for electrophoresis, chromatography, and crystallography applications. Its critical micelle concentration (CMC) of ~0.1 mM ensures effective protein stabilization without interference with downstream analyses. Provided as a crystalline solid with >98% purity, our Zwittergent 3-14 is rigorously tested for low…

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Description

Description

Zwittergent 3-14 (CAS No. 1514-82-5) is a high-purity zwitterionic detergent widely utilized in biochemical and biophysical research. Its molecular formula, C19H41NO3S, reflects its unique structure as 3-[dimethyl(tetradecyl)azaniumyl]propane-1-sulfonate, combining a 14-carbon alkyl chain with a quaternary ammonium group and a sulfonate moiety. This amphoteric surfactant exhibits exceptional solubilizing properties for membrane proteins while maintaining their native conformation, making it ideal for electrophoresis, chromatography, and crystallography applications. Its critical micelle concentration (CMC) of ~0.1 mM ensures effective protein stabilization without interference with downstream analyses. Provided as a crystalline solid with >98% purity, our Zwittergent 3-14 is rigorously tested for low UV absorbance and heavy metal content, meeting the stringent requirements of structural biology research.

  • CAS No: 1514-82-5
  • Molecular Formula: C19H41NO3S
  • Molecular Weight: 363.6
  • Exact Mass: 363.28071534
  • Monoisotopic Mass: 363.28071534
  • IUPAC Name: 3-[dimethyl(tetradecyl)azaniumyl]propane-1-sulfonate
  • SMILES: CCCCCCCCCCCCCC[N+](C)(C)CCCS(=O)(=O)[O-]
  • Synonyms: 14933-09-6, Zwittergent 3-14, Dimethyl(3-sulphonatopropyl)tetradecylammonium, EINECS 239-003-9, 1-Tetradecanaminium, N,N-dimethyl-N-(3-sulfopropyl)-, inner salt

Application

Zwittergent 3-14 is extensively employed in membrane protein isolation, where its zwitterionic nature enables gentle extraction while preserving protein activity. It serves as a key component in 2D electrophoresis buffers for improving resolution of hydrophobic proteins. Researchers utilize this detergent for solubilizing integral membrane proteins in X-ray crystallography studies due to its minimal interference with crystallization. Its compatibility with mass spectrometry makes it valuable for proteomics workflows requiring MS-compatible detergents.

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