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Atomfair Uridine, 2′-deoxy-5-iodo- C9H11IN2O5

Description Uridine, 2′-deoxy-5-iodo- (CAS No. 54-42-2) is a modified nucleoside with the molecular formula C9H11IN2O5and IUPAC name 1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione . This halogenated derivative of deoxyuridine is a critical reagent in molecular biology, antiviral research, and nucleic acid chemistry. The compound features an iodine substitution at the 5-position of the uracil ring, enhancing its utility as a radioactive tracer (when labeled with I-125) and as a building block for modified oligonucleotides. With high purity (>98%) as verified by HPLC, this product is supplied as a white to off-white crystalline powder under inert atmosphere to ensure stability. Suitable for use in PCR applications,…

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Description

Description

Uridine, 2′-deoxy-5-iodo- (CAS No. 54-42-2) is a modified nucleoside with the molecular formula C9H11IN2O5 and IUPAC name 1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione. This halogenated derivative of deoxyuridine is a critical reagent in molecular biology, antiviral research, and nucleic acid chemistry. The compound features an iodine substitution at the 5-position of the uracil ring, enhancing its utility as a radioactive tracer (when labeled with I-125) and as a building block for modified oligonucleotides. With high purity (>98%) as verified by HPLC, this product is supplied as a white to off-white crystalline powder under inert atmosphere to ensure stability. Suitable for use in PCR applications, antiviral mechanism studies, and as a reference standard in analytical chemistry.

  • CAS No: 54-42-2
  • Molecular Formula: C9H11IN2O5
  • Molecular Weight: 354.10
  • Exact Mass: 353.97127
  • Monoisotopic Mass: 353.97127
  • IUPAC Name: 1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione
  • SMILES: C1C(C(OC1N2C=C(C(=O)NC2=O)I)CO)O
  • Synonyms: Ophthalmadine, Herpesil, Herpidu, Iducher, Synmiol

Application

2′-Deoxy-5-iodouridine serves as a key intermediate in the synthesis of antiviral compounds, particularly for herpesvirus research. The iodine modification allows for radiolabeling studies to track nucleotide incorporation in viral DNA replication. Researchers utilize this compound to investigate nucleoside analog metabolism and as a chain terminator in DNA sequencing applications. Its unique structure enables studies of enzyme-substrate interactions in thymidine kinase and other nucleoside-processing enzymes.

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