Atomfair Trimethylsilyl triflate TMSOTf C4H9F3O3SSi

Description Trimethylsilyl triflate (CAS No. 27607-77-8) is a highly reactive organosilicon compound with the molecular formula C4H9F3O3SSi . Also known as trimethylsilyl trifluoromethanesulfonate , this versatile reagent is widely used as a powerful silylating agent and Lewis acid catalyst in organic synthesis. Its strong affinity for oxygen and nitrogen nucleophiles makes it ideal for protecting group chemistry, glycosylation reactions, and the activation of inert functional groups. The compound is moisture-sensitive and typically handled under inert conditions. Available in high-purity grades, our Trimethylsilyl triflate is rigorously tested for quality, ensuring optimal performance in demanding research applications.

Description

Trimethylsilyl triflate (CAS No. 27607-77-8) is a highly reactive organosilicon compound with the molecular formula C₄H₉F₃O₃SSi. Also known as trimethylsilyl trifluoromethanesulfonate, this versatile reagent is widely used as a powerful silylating agent and Lewis acid catalyst in organic synthesis. Its strong affinity for oxygen and nitrogen nucleophiles makes it ideal for protecting group chemistry, glycosylation reactions, and the activation of inert functional groups. The compound is moisture-sensitive and typically handled under inert conditions. Available in high-purity grades, our Trimethylsilyl triflate is rigorously tested for quality, ensuring optimal performance in demanding research applications.

CAS No: 27607-77-8
Molecular Formula: C4H9F3O3SSi
Molecular Weight: 222.26
Exact Mass: 221.99937634
Monoisotopic Mass: 221.99937634
IUPAC Name: trimethylsilyl trifluoromethanesulfonate
SMILES: C[Si](C)(C)OS(=O)(=O)C(F)(F)F
Synonyms: Trimethylsilyl trifluoromethanesulfonate, 27607-77-8, Trimethylsilyl triflate, Trimethylsilyl trifluoromethanesulphonate, Trimethylsilyl trifluoromethylsulfonate

Application

Trimethylsilyl triflate is extensively used in organic synthesis as a catalyst for glycosylation reactions, enabling the formation of complex carbohydrate structures. It serves as a potent silylating agent for the protection of alcohols, amines, and other nucleophilic functional groups. The compound is also employed in the activation of carbonyl compounds and the synthesis of silicon-containing intermediates. Its strong Lewis acidity makes it valuable in polymerization and rearrangement reactions.

If you are interested or have any questions, please contact us at support@atomfair.com