Atomfair Trimethylsilyl chlorosulphate C3H9ClO3SSi

Description Trimethylsilyl chlorosulphate (CAS No. 4353-77-9) is a highly reactive organosilicon compound with the molecular formula C3H9ClO3SSi . Also known by its IUPAC name, [chlorosulfonyloxy(dimethyl)silyl]methane , this chemical is widely utilized as a silylating agent and electrophile in organic synthesis. Its unique structure, featuring both a chlorosulfonate group and a trimethylsilyl moiety, enables versatile applications in protecting group chemistry and as a reagent for introducing sulfonate esters. This compound is typically supplied as a clear, colorless to pale yellow liquid with high purity (>98%) and must be stored under inert conditions due to its moisture sensitivity. Suitable for advanced research…

Description

Trimethylsilyl chlorosulphate (CAS No. 4353-77-9) is a highly reactive organosilicon compound with the molecular formula C₃H₉ClO₃SSi. Also known by its IUPAC name, [chlorosulfonyloxy(dimethyl)silyl]methane, this chemical is widely utilized as a silylating agent and electrophile in organic synthesis. Its unique structure, featuring both a chlorosulfonate group and a trimethylsilyl moiety, enables versatile applications in protecting group chemistry and as a reagent for introducing sulfonate esters. This compound is typically supplied as a clear, colorless to pale yellow liquid with high purity (>98%) and must be stored under inert conditions due to its moisture sensitivity. Suitable for advanced research and industrial processes, Trimethylsilyl chlorosulphate is a valuable tool for synthetic chemists working in pharmaceuticals, agrochemicals, and material science.

CAS No: 4353-77-9
Molecular Formula: C3H9ClO3SSi
Molecular Weight: 188.71
Exact Mass: 187.9730195
Monoisotopic Mass: 187.9730195
IUPAC Name: [chlorosulfonyloxy(dimethyl)silyl]methane
SMILES: C[Si](C)(C)OS(=O)(=O)Cl
Synonyms: 4353-77-9, Trimethylsilyl chlorosulfonate, Trimethylsilyl chlorosulphate, EINECS 224-425-8, DTXSID30195872

Application

Trimethylsilyl chlorosulphate is primarily employed as a silylating agent for the protection of hydroxyl and carboxyl groups in complex organic syntheses. It serves as a key intermediate in the preparation of sulfonate esters and sulfonyl derivatives, which are critical in drug discovery and polymer chemistry. Additionally, this reagent is used in the activation of carboxylic acids for peptide coupling reactions and in the modification of silica surfaces for chromatographic applications.

If you are interested or have any questions, please contact us at support@atomfair.com