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Atomfair Trifluoroacetaldehyde C2HF3O

Description Trifluoroacetaldehyde (CAS No. 421-53-4), also known as 2,2,2-trifluoroacetaldehyde, is a highly reactive fluorinated aldehyde with the molecular formula C2HF3O . This colorless to pale yellow liquid is a versatile building block in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty materials. Its strong electron-withdrawing trifluoromethyl group enhances reactivity, making it invaluable for nucleophilic addition reactions, cyclizations, and as a precursor to trifluoromethylated compounds. Trifluoroacetaldehyde is handled under inert conditions due to its sensitivity to moisture and air. Packaged in sealed ampules or under nitrogen to ensure stability, this high-purity reagent is ideal for research and industrial…

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Description

Description

Trifluoroacetaldehyde (CAS No. 421-53-4), also known as 2,2,2-trifluoroacetaldehyde, is a highly reactive fluorinated aldehyde with the molecular formula C2HF3O. This colorless to pale yellow liquid is a versatile building block in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty materials. Its strong electron-withdrawing trifluoromethyl group enhances reactivity, making it invaluable for nucleophilic addition reactions, cyclizations, and as a precursor to trifluoromethylated compounds. Trifluoroacetaldehyde is handled under inert conditions due to its sensitivity to moisture and air. Packaged in sealed ampules or under nitrogen to ensure stability, this high-purity reagent is ideal for research and industrial applications demanding precise fluorination chemistry.

  • CAS No: 421-53-4
  • Molecular Formula: C2HF3O
  • Molecular Weight: 98.02
  • Exact Mass: 97.99794914
  • Monoisotopic Mass: 97.99794914
  • IUPAC Name: 2,2,2-trifluoroacetaldehyde
  • SMILES: C(=O)C(F)(F)F
  • Synonyms: Trifluoroacetaldehyde, 75-90-1, Acetaldehyde, trifluoro-, NSC 9446, EINECS 200-914-1

Application

Trifluoroacetaldehyde is widely used as a key intermediate in the synthesis of trifluoromethyl-containing compounds, which are prevalent in pharmaceuticals and agrochemicals due to their enhanced metabolic stability and lipophilicity. It serves as a precursor for the production of trifluoroethanol, trifluoroacetic acid, and other fluorinated derivatives. In material science, it is employed to modify polymers and coatings, imparting unique chemical resistance and surface properties. Researchers also utilize it in asymmetric catalysis and the development of novel fluorinated heterocycles.

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