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Atomfair Rimegepant BMS-927711, BHV-3000 C28H28F2N6O3

Description Rimegepant (CAS No. 1374024-48-2) is a high-purity, small-molecule calcitonin gene-related peptide (CGRP) receptor antagonist with the molecular formula C28H28F2N6O3. This compound, also known by its IUPAC name [(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl] 4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate , is a selective and orally bioavailable therapeutic agent. It is widely utilized in neurological research, particularly for its efficacy in migraine treatment and prevention. Rimegepant is supplied as a lyophilized powder or in solution, with ??98% purity confirmed by HPLC and LC-MS analysis. Store at -20??C under inert conditions for optimal stability.

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Description

Description

Rimegepant (CAS No. 1374024-48-2) is a high-purity, small-molecule calcitonin gene-related peptide (CGRP) receptor antagonist with the molecular formula C28H28F2N6O3. This compound, also known by its IUPAC name [(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl] 4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate, is a selective and orally bioavailable therapeutic agent. It is widely utilized in neurological research, particularly for its efficacy in migraine treatment and prevention. Rimegepant is supplied as a lyophilized powder or in solution, with ??98% purity confirmed by HPLC and LC-MS analysis. Store at -20??C under inert conditions for optimal stability.

  • CAS No: 1374024-48-2
  • Molecular Formula: C28H28F2N6O3
  • Molecular Weight: 534.6
  • Exact Mass: 534.21909510
  • Monoisotopic Mass: 534.21909510
  • IUPAC Name: [(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl] 4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate
  • SMILES: C1C[C@H](C2=C(C=CC=N2)[C@H]([C@@H]1C3=C(C(=CC=C3)F)F)N)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
  • Synonyms: Rimegepant, 1289023-67-1, BMS-927711, BMS 927711, BHV-3000

Application

Rimegepant is primarily used in preclinical and clinical research as a potent and selective CGRP receptor antagonist for the acute treatment and prevention of migraines. It demonstrates high binding affinity and efficacy in blocking CGRP-mediated vasodilation and neurogenic inflammation. Researchers also investigate its potential therapeutic applications in chronic pain disorders and trigeminal autonomic cephalalgias.

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