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Atomfair (R)-Nomega-(t-Butoxycarbonyl)-Nalpha-(9-fluorenylmethoxycarbonyl)-alpha-methylornithin Fmoc-??-Me-D-Orn(Boc)-OH C26H32N2O6

Description (R)-N??-(t-Butoxycarbonyl)-N??-(9-fluorenylmethoxycarbonyl)-??-methylornithine (CAS No. 171860-40-5) is a high-purity, protected amino acid derivative designed for peptide synthesis and biochemical research. This compound features a molecular formula of C26H32N2O6and is characterized by its dual protection with tert -butoxycarbonyl (Boc) and fluorenylmethoxycarbonyl (Fmoc) groups, ensuring selective deprotection during solid-phase peptide synthesis (SPPS). The ??-methyl substitution introduces steric constraints, making it valuable for studying peptide conformation and stability. Ideal for researchers in medicinal chemistry and drug discovery, this product is rigorously tested for purity (??95% by HPLC) and is supplied as a white to off-white crystalline powder. Store at -20??C under inert conditions to…

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Description

Description

(R)-N??-(t-Butoxycarbonyl)-N??-(9-fluorenylmethoxycarbonyl)-??-methylornithine (CAS No. 171860-40-5) is a high-purity, protected amino acid derivative designed for peptide synthesis and biochemical research. This compound features a molecular formula of C26H32N2O6 and is characterized by its dual protection with tert-butoxycarbonyl (Boc) and fluorenylmethoxycarbonyl (Fmoc) groups, ensuring selective deprotection during solid-phase peptide synthesis (SPPS). The ??-methyl substitution introduces steric constraints, making it valuable for studying peptide conformation and stability. Ideal for researchers in medicinal chemistry and drug discovery, this product is rigorously tested for purity (??95% by HPLC) and is supplied as a white to off-white crystalline powder. Store at -20??C under inert conditions to maintain stability.

  • CAS No: 171860-40-5
  • Molecular Formula: C26H32N2O6
  • Molecular Weight: 468.5
  • Exact Mass: 468.22603674
  • Monoisotopic Mass: 468.22603674
  • IUPAC Name: (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-methyl-5-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid
  • SMILES: C[C@@](CCCNC(=O)OC(C)(C)C)(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
  • Synonyms: 171860-40-5, (R)-Nomega-(t-Butoxycarbonyl)-Nalpha-(9-fluorenylmethoxycarbonyl)-alpha-methylornithin, 691-378-1, Fmoc-Alpha-Me-D-Orn(Boc)-OH, (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-methyl-5-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid

Application

This compound is widely used in peptide synthesis, particularly for introducing ??-methylornithine residues into peptide chains to modulate backbone flexibility and proteolytic resistance. It serves as a key intermediate in the development of constrained peptidomimetics and enzyme inhibitors. Researchers also employ it in the study of structure-activity relationships (SAR) due to its stereospecific (R)-configuration. Its dual Boc/Fmoc protection allows for orthogonal deprotection strategies in multi-step syntheses.

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