Description

Description

Pyridine-3-sulfonyl chloride (CAS No. 813222-82-1) is a high-purity sulfonylation reagent widely used in organic synthesis and pharmaceutical research. This compound, with the molecular formula C₅H₄ClNO₂S, is a versatile building block for introducing the pyridine-3-sulfonyl moiety into target molecules. Its IUPAC name, pyridine-3-sulfonyl chloride, reflects its precise chemical structure, featuring a reactive sulfonyl chloride group attached to the 3-position of a pyridine ring.

Our product is rigorously tested to ensure exceptional quality, with purity levels suitable for demanding research applications. It is supplied in a stable, moisture-sensitive form and should be stored under inert conditions to maintain reactivity. Pyridine-3-sulfonyl chloride is particularly valuable in medicinal chemistry for the synthesis of sulfonamide derivatives, which are important pharmacophores in drug discovery.

Key synonyms include: 3-Pyridinesulfonyl chloride, DTXSID70936483, and DTXCID80970398. This compound is an essential tool for researchers working on enzyme inhibitors, receptor modulators, and other biologically active molecules where the pyridine sulfonyl group can enhance binding affinity or modify physicochemical properties.

Application

Pyridine-3-sulfonyl chloride serves as a key intermediate in the synthesis of sulfonamide compounds with potential pharmaceutical applications. It is particularly useful in medicinal chemistry for creating targeted inhibitors of enzymes or receptors that recognize the pyridine sulfonyl motif. Researchers employ this reagent to modify peptides or small molecules, enhancing their biological activity or pharmacokinetic properties. The compound’s reactivity makes it valuable for parallel synthesis and combinatorial chemistry approaches in drug discovery programs.

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