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Atomfair N-Hydroxysuccinimide NHS C4H5NO3

Description N-Hydroxysuccinimide (NHS) (CAS No. 62439-33-2) is a highly versatile and widely used organic compound with the molecular formula C4H5NO3. This white crystalline solid is a key reagent in bioconjugation and peptide synthesis, particularly as an activating agent for carboxylic acids in the formation of NHS esters. Its IUPAC name, 1-hydroxypyrrolidine-2,5-dione , reflects its cyclic succinimide structure with a hydroxyl group. NHS is renowned for its stability, high reactivity, and compatibility with aqueous and organic solvents, making it indispensable in protein crosslinking, antibody labeling, and polymer chemistry. Packaged under inert conditions to ensure purity and longevity, our NHS is rigorously…

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Description

Description

N-Hydroxysuccinimide (NHS) (CAS No. 62439-33-2) is a highly versatile and widely used organic compound with the molecular formula C4H5NO3. This white crystalline solid is a key reagent in bioconjugation and peptide synthesis, particularly as an activating agent for carboxylic acids in the formation of NHS esters. Its IUPAC name, 1-hydroxypyrrolidine-2,5-dione, reflects its cyclic succinimide structure with a hydroxyl group. NHS is renowned for its stability, high reactivity, and compatibility with aqueous and organic solvents, making it indispensable in protein crosslinking, antibody labeling, and polymer chemistry. Packaged under inert conditions to ensure purity and longevity, our NHS is rigorously tested to meet the highest standards for research and industrial applications.

  • CAS No: 62439-33-2
  • Molecular Formula: C4H5NO3
  • Molecular Weight: 115.09
  • Exact Mass: 115.026943022
  • Monoisotopic Mass: 115.026943022
  • IUPAC Name: 1-hydroxypyrrolidine-2,5-dione
  • SMILES: C1CC(=O)N(C1=O)O
  • Synonyms: N-Hydroxysuccinimide, 6066-82-6, 1-hydroxypyrrolidine-2,5-dione, 1-Hydroxysuccinimide, 1-Hydroxy-2,5-pyrrolidinedione

Application

N-Hydroxysuccinimide (NHS) is primarily used to activate carboxyl groups for amide bond formation with amines, facilitating peptide coupling and bioconjugation. It is a critical component in EDC/NHS coupling chemistry, enabling the modification of proteins, antibodies, and other biomolecules for diagnostics and therapeutics. NHS esters are also employed in surface functionalization, hydrogel synthesis, and the preparation of affinity chromatography resins. Its applications extend to materials science for polymer crosslinking and nanoparticle functionalization.

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