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Atomfair Methyl (2R,3R)-1-Boc-3-fluoropyrrolidine-2-carboxylate C11H18FNO4

Description Methyl (2R,3R)-1-Boc-3-fluoropyrrolidine-2-carboxylate (CAS: 2454490-53-8) is a high-purity fluorinated pyrrolidine derivative, widely utilized in pharmaceutical research and organic synthesis. This compound features a tert -butoxycarbonyl (Boc) protecting group and a methyl ester moiety, making it an essential intermediate for the development of bioactive molecules, peptidomimetics, and chiral catalysts. With the molecular formula C11H18FNO4and an IUPAC name of 1-O-tert-butyl 2-O-methyl 3-fluoropyrrolidine-1,2-dicarboxylate , it offers exceptional stereochemical control for asymmetric synthesis. Available in rigorously tested batches (>95% purity by HPLC), this reagent is ideal for medicinal chemistry, fluorination studies, and proteomics applications. Packaged under inert gas to ensure stability, it is supplied…

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Description

Description

Methyl (2R,3R)-1-Boc-3-fluoropyrrolidine-2-carboxylate (CAS: 2454490-53-8) is a high-purity fluorinated pyrrolidine derivative, widely utilized in pharmaceutical research and organic synthesis. This compound features a tert-butoxycarbonyl (Boc) protecting group and a methyl ester moiety, making it an essential intermediate for the development of bioactive molecules, peptidomimetics, and chiral catalysts. With the molecular formula C11H18FNO4 and an IUPAC name of 1-O-tert-butyl 2-O-methyl 3-fluoropyrrolidine-1,2-dicarboxylate, it offers exceptional stereochemical control for asymmetric synthesis. Available in rigorously tested batches (>95% purity by HPLC), this reagent is ideal for medicinal chemistry, fluorination studies, and proteomics applications. Packaged under inert gas to ensure stability, it is supplied in amber vials to prevent light-induced degradation.

  • CAS No: 2454490-53-8
  • Molecular Formula: C11H18FNO4
  • Molecular Weight: 247.26
  • Exact Mass: 247.12198622
  • Monoisotopic Mass: 247.12198622
  • IUPAC Name: 1-O-tert-butyl 2-O-methyl 3-fluoropyrrolidine-1,2-dicarboxylate
  • SMILES: CC(C)(C)OC(=O)N1CCC(C1C(=O)OC)F
  • Synonyms: Methyl (2R,3S)-1-Boc-3-fluoropyrrolidine-2-carboxylate, SCHEMBL201931, MFCD28126856, MFCD28126862, SY321587

Application

This compound serves as a key chiral building block in the synthesis of fluorinated pharmaceuticals, particularly in the development of protease inhibitors and CNS-targeting drugs. Its Boc-protected amine and methyl ester functionalities facilitate further derivatization under mild conditions. Researchers employ it in peptide backbone modifications to enhance metabolic stability and bioavailability. Additionally, it is used in organocatalysis and as a precursor for fluorinated heterocycles in agrochemical research.

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