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Atomfair Methanesulfonamide,N,N’-(1R,2R)-1,2-cyclohexanediylbis[1,1,1-trifluoro- C8H12F6N2O4S2

Description Methanesulfonamide,N,N’-(1R,2R)-1,2-cyclohexanediylbis[1,1,1-trifluoro- (CAS No. 122833-60-7) is a high-purity specialty chemical with the molecular formula C8H12F6N2O4S2. This compound, also known by its IUPAC name 1,1,1-trifluoro-N-[2-(trifluoromethylsulfonylamino)cyclohexyl]methanesulfonamide , is a chiral bis(trifluoromethanesulfonamide) derivative featuring a cyclohexane backbone. Its unique structural properties, including the presence of multiple sulfonamide and trifluoromethyl groups, make it a valuable intermediate in organic synthesis and pharmaceutical research. The compound is supplied as a white to off-white crystalline solid with a high degree of stereochemical purity (>98% ee). It is soluble in common organic solvents such as DMSO, DMF, and dichloromethane, but has limited solubility in water. Proper storage conditions…

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Description

Description

Methanesulfonamide,N,N’-(1R,2R)-1,2-cyclohexanediylbis[1,1,1-trifluoro- (CAS No. 122833-60-7) is a high-purity specialty chemical with the molecular formula C8H12F6N2O4S2. This compound, also known by its IUPAC name 1,1,1-trifluoro-N-[2-(trifluoromethylsulfonylamino)cyclohexyl]methanesulfonamide, is a chiral bis(trifluoromethanesulfonamide) derivative featuring a cyclohexane backbone. Its unique structural properties, including the presence of multiple sulfonamide and trifluoromethyl groups, make it a valuable intermediate in organic synthesis and pharmaceutical research. The compound is supplied as a white to off-white crystalline solid with a high degree of stereochemical purity (>98% ee). It is soluble in common organic solvents such as DMSO, DMF, and dichloromethane, but has limited solubility in water. Proper storage conditions (2-8??C in a tightly sealed container under inert atmosphere) are recommended to maintain stability.

  • CAS No: 122833-60-7
  • Molecular Formula: C8H12F6N2O4S2
  • Molecular Weight: 378.3
  • Exact Mass: 378.01426819
  • Monoisotopic Mass: 378.01426819
  • IUPAC Name: 1,1,1-trifluoro-N-[2-(trifluoromethylsulfonylamino)cyclohexyl]methanesulfonamide
  • SMILES: C1CCC(C(C1)NS(=O)(=O)C(F)(F)F)NS(=O)(=O)C(F)(F)F
  • Synonyms: Methanesulfonamide,N,N’-(1R,2R)-1,2-cyclohexanediylbis[1,1,1-trifluoro-, SCHEMBL3381296, GKSGSDYYIYURPD-UHFFFAOYSA-N, 1,1,1-TRIFLUORO-N-[(1R,2R)-2-(TRIFLUOROMETHANESULFONAMIDO)CYCLOHEXYL]METHANESULFONAMIDE, AKOS024288292

Application

This chiral bis(trifluoromethanesulfonamide) compound serves as a versatile building block in asymmetric synthesis and medicinal chemistry. Researchers utilize it as a precursor for designing novel catalysts in enantioselective transformations. The electron-withdrawing trifluoromethylsulfonyl groups make it particularly useful in the development of pharmaceutical intermediates with enhanced metabolic stability. Additionally, its rigid cyclohexane scaffold finds applications in molecular recognition studies and as a template for constrained peptidomimetics.

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