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Atomfair Gefapixant citrate MK-7264 C20H27N5O11S

Description Gefapixant citrate (CAS No. 2310299-91-1) is a high-purity pharmaceutical compound with the molecular formula C20H27N5O11S . It is chemically described as 5-(2,4-diaminopyrimidin-5-yl)oxy-2-methoxy-4-propan-2-ylbenzenesulfonamide;2-hydroxypropane-1,2,3-tricarboxylic acid . This compound is a selective P2X3 receptor antagonist, developed for therapeutic applications in chronic cough and related respiratory conditions. Gefapixant citrate is supplied as a white to off-white crystalline powder, with rigorous quality control to ensure ??98% purity (HPLC). Suitable for research and development, this product is ideal for pharmacological studies, preclinical trials, and analytical reference standards. Store at -20??C under inert conditions to maintain stability.

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Description

Description

Gefapixant citrate (CAS No. 2310299-91-1) is a high-purity pharmaceutical compound with the molecular formula C20H27N5O11S. It is chemically described as 5-(2,4-diaminopyrimidin-5-yl)oxy-2-methoxy-4-propan-2-ylbenzenesulfonamide;2-hydroxypropane-1,2,3-tricarboxylic acid. This compound is a selective P2X3 receptor antagonist, developed for therapeutic applications in chronic cough and related respiratory conditions. Gefapixant citrate is supplied as a white to off-white crystalline powder, with rigorous quality control to ensure ??98% purity (HPLC). Suitable for research and development, this product is ideal for pharmacological studies, preclinical trials, and analytical reference standards. Store at -20??C under inert conditions to maintain stability.

  • CAS No: 2310299-91-1
  • Molecular Formula: C20H27N5O11S
  • Molecular Weight: 545.5
  • Exact Mass: 545.14277787
  • Monoisotopic Mass: 545.14277787
  • IUPAC Name: 5-(2,4-diaminopyrimidin-5-yl)oxy-2-methoxy-4-propan-2-ylbenzenesulfonamide;2-hydroxypropane-1,2,3-tricarboxylic acid
  • SMILES: CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)S(=O)(=O)N)OC.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
  • Synonyms: Gefapixant citrate, 2310299-91-1, DFK0FC2VVV, Gefapixant citrate [USAN], MK-7264

Application

Gefapixant citrate is primarily investigated as a therapeutic agent for refractory or unexplained chronic cough due to its selective P2X3 receptor antagonism. It modulates afferent nerve signaling in the respiratory tract, reducing cough reflex hypersensitivity. This compound has shown efficacy in clinical trials for improving cough frequency and quality of life in patients. Researchers utilize it to explore novel treatments for neurogenic cough and other P2X3-mediated conditions.

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