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Atomfair Ethyl 6-(trifluoromethyl)-1H-indole-2-carboxylate C12H10F3NO2

Description Ethyl 6-(trifluoromethyl)-1H-indole-2-carboxylate (CAS No. 327-21-9) is a high-purity fluorinated indole derivative with the molecular formula C12H10F3NO2. This compound features a trifluoromethyl group at the 6-position of the indole ring and an ethyl ester moiety at the 2-position, making it a versatile building block for pharmaceutical and agrochemical research. It is supplied as a crystalline solid with ??97% purity (HPLC), ensuring optimal performance in synthetic applications. Suitable for use in cross-coupling reactions, heterocyclic chemistry, and as a precursor for bioactive molecules. Packaged under inert gas to enhance stability and shipped with comprehensive analytical data (NMR, MS, HPLC).

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Description

Description

Ethyl 6-(trifluoromethyl)-1H-indole-2-carboxylate (CAS No. 327-21-9) is a high-purity fluorinated indole derivative with the molecular formula C12H10F3NO2. This compound features a trifluoromethyl group at the 6-position of the indole ring and an ethyl ester moiety at the 2-position, making it a versatile building block for pharmaceutical and agrochemical research. It is supplied as a crystalline solid with ??97% purity (HPLC), ensuring optimal performance in synthetic applications. Suitable for use in cross-coupling reactions, heterocyclic chemistry, and as a precursor for bioactive molecules. Packaged under inert gas to enhance stability and shipped with comprehensive analytical data (NMR, MS, HPLC).

  • CAS No: 327-21-9
  • Molecular Formula: C12H10F3NO2
  • Molecular Weight: 257.21
  • Exact Mass: 257.06636305
  • Monoisotopic Mass: 257.06636305
  • IUPAC Name: ethyl 6-(trifluoromethyl)-1H-indole-2-carboxylate
  • SMILES: CCOC(=O)C1=CC2=C(N1)C=C(C=C2)C(F)(F)F
  • Synonyms: Ethyl 6-(trifluoromethyl)-1H-indole-2-carboxylate, 327-21-9, DTXSID50624614, DTXCID80575367, 892-135-4

Application

Ethyl 6-(trifluoromethyl)-1H-indole-2-carboxylate is widely used in medicinal chemistry as a key intermediate for the synthesis of trifluoromethyl-substituted indole scaffolds. Its electron-withdrawing CF3 group enhances metabolic stability in drug candidates, particularly for CNS and oncology targets. Researchers also employ it in the development of fluorescent probes and agrochemicals due to its unique photophysical properties.

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