Atomfair Diethyl 4-Methylbenzylphosphonate C12H19O3P

Description Diethyl 4-Methylbenzylphosphonate (CAS No. 3971-31-1) is a high-purity organophosphorus compound with the molecular formula C12H19O3P . This versatile reagent is widely used in organic synthesis, particularly in Horner-Wadsworth-Emmons (HWE) reactions for the preparation of alkenes. Its IUPAC name, 1-(diethoxyphosphorylmethyl)-4-methylbenzene , reflects its structural features: a phosphonate ester group attached to a 4-methylbenzyl moiety. The compound is supplied as a clear, colorless to pale yellow liquid with a typical purity of ??95% (GC). It is moisture-sensitive and should be stored under inert gas (N2or Ar) at 2-8??C. Suitable for use in pharmaceutical intermediates, agrochemical synthesis, and materials science research.

Description

Diethyl 4-Methylbenzylphosphonate (CAS No. 3971-31-1) is a high-purity organophosphorus compound with the molecular formula C₁₂H₁₉O₃P. This versatile reagent is widely used in organic synthesis, particularly in Horner-Wadsworth-Emmons (HWE) reactions for the preparation of alkenes. Its IUPAC name, 1-(diethoxyphosphorylmethyl)-4-methylbenzene, reflects its structural features: a phosphonate ester group attached to a 4-methylbenzyl moiety. The compound is supplied as a clear, colorless to pale yellow liquid with a typical purity of ??95% (GC). It is moisture-sensitive and should be stored under inert gas (N₂ or Ar) at 2-8??C. Suitable for use in pharmaceutical intermediates, agrochemical synthesis, and materials science research.

CAS No: 3971-31-1
Molecular Formula: C12H19O3P
Molecular Weight: 242.25
Exact Mass: 242.10718146
Monoisotopic Mass: 242.10718146
IUPAC Name: 1-(diethoxyphosphorylmethyl)-4-methylbenzene
SMILES: CCOP(=O)(CC1=CC=C(C=C1)C)OCC
Synonyms: diethyl 4-methylbenzylphosphonate, 3762-25-2, Diethyl (4-methylbenzyl)phosphonate, 1-(diethoxyphosphorylmethyl)-4-methylbenzene, KR7824QXJ2

Application

Diethyl 4-Methylbenzylphosphonate serves as a key building block in organic synthesis, particularly in the preparation of ??,??-unsaturated esters via Horner-Wadsworth-Emmons olefination. It finds application in the synthesis of pharmaceutical intermediates, especially those containing styrene derivatives. Researchers utilize this phosphonate in materials science for modifying aromatic compounds with phosphonate functional groups. The 4-methylbenzyl group offers enhanced stability and reactivity in palladium-catalyzed coupling reactions.

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