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Atomfair Benzoic acid, 4-[[(trifluoromethyl)sulfonyl]oxy]-, ethyl ester C10H9F3O5S

Description Ethyl 4-(Trifluoromethylsulfonyloxy)benzoate (CAS No. 125261-30-5) is a high-purity synthetic organic compound with the molecular formula C10H9F3O5S . This ester derivative of benzoic acid features a trifluoromethylsulfonyloxy ( -OSO2CF3) group at the para position, making it a valuable triflate ( trifluoromethanesulfonate ) reagent for advanced organic synthesis and pharmaceutical research. The compound is supplied as a crystalline solid or in solution, with rigorous QC ensuring >98% purity (HPLC). Its unique structure enables versatile reactivity in cross-coupling reactions , nucleophilic substitutions , and as a precursor for functionalized aromatic systems . Ideal for Suzuki-Miyaura, Heck, and Buchwald-Hartwig reactions. Store under inert…

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Description

Description

Ethyl 4-(Trifluoromethylsulfonyloxy)benzoate (CAS No. 125261-30-5) is a high-purity synthetic organic compound with the molecular formula C10H9F3O5S. This ester derivative of benzoic acid features a trifluoromethylsulfonyloxy (-OSO2CF3) group at the para position, making it a valuable triflate (trifluoromethanesulfonate) reagent for advanced organic synthesis and pharmaceutical research. The compound is supplied as a crystalline solid or in solution, with rigorous QC ensuring >98% purity (HPLC). Its unique structure enables versatile reactivity in cross-coupling reactions, nucleophilic substitutions, and as a precursor for functionalized aromatic systems. Ideal for Suzuki-Miyaura, Heck, and Buchwald-Hartwig reactions. Store under inert atmosphere at -20??C to prevent hydrolysis.

  • CAS No: 125261-30-5
  • Molecular Formula: C10H9F3O5S
  • Molecular Weight: 298.24
  • Exact Mass: 298.01227904
  • Monoisotopic Mass: 298.01227904
  • IUPAC Name: ethyl 4-(trifluoromethylsulfonyloxy)benzoate
  • SMILES: CCOC(=O)C1=CC=C(C=C1)OS(=O)(=O)C(F)(F)F
  • Synonyms: 125261-30-5, Benzoic acid, 4-[[(trifluoromethyl)sulfonyl]oxy]-, ethyl ester, ETHYL 4-(TRIFLUOROMETHANESULFONYLOXY)BENZOATE, SCHEMBL14720856, p-(ethoxycarbonyl)phenyl triflate

Application

This triflate ester serves as a key electrophile in palladium-catalyzed coupling reactions for constructing biaryl systems in drug discovery. The electron-withdrawing triflyloxy group enhances reactivity in SNAr reactions with amines and thiols. Researchers utilize it to introduce para-ester functionalization in materials science applications, particularly in liquid crystal and polymer synthesis. Its stability allows for storage as a bench-stable coupling partner.

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