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Atomfair 8-Bromo-2′-deoxyadenosine 8-B-2-DA C10H12BrN5O3

Description 8-Bromo-2′-deoxyadenosine (CAS No. 15223-20-8) is a modified nucleoside analog featuring a bromine substitution at the 8-position of the adenine base. This compound, with the molecular formula C10H12BrN5O3, is a valuable biochemical tool for researchers studying nucleic acid structure, function, and interactions. The IUPAC name, (2R,3S,5R)-5-(6-amino-8-bromopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol, highlights its stereochemistry and functional groups. This product is supplied as a high-purity solid, rigorously tested via HPLC, NMR, and mass spectrometry to ensure quality and consistency. Ideal for oligonucleotide synthesis, enzymatic studies, and structural biology applications, 8-Bromo-2′-deoxyadenosine is a critical reagent for probing DNA-protein interactions and designing modified nucleic acid probes.

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Description

Description

8-Bromo-2′-deoxyadenosine (CAS No. 15223-20-8) is a modified nucleoside analog featuring a bromine substitution at the 8-position of the adenine base. This compound, with the molecular formula C10H12BrN5O3, is a valuable biochemical tool for researchers studying nucleic acid structure, function, and interactions. The IUPAC name, (2R,3S,5R)-5-(6-amino-8-bromopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol, highlights its stereochemistry and functional groups. This product is supplied as a high-purity solid, rigorously tested via HPLC, NMR, and mass spectrometry to ensure quality and consistency. Ideal for oligonucleotide synthesis, enzymatic studies, and structural biology applications, 8-Bromo-2′-deoxyadenosine is a critical reagent for probing DNA-protein interactions and designing modified nucleic acid probes.

  • CAS No: 15223-20-8
  • Molecular Formula: C10H12BrN5O3
  • Molecular Weight: 330.14
  • Exact Mass: 329.01235
  • Monoisotopic Mass: 329.01235
  • IUPAC Name: (2R,3S,5R)-5-(6-amino-8-bromopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
  • SMILES: C1[C@@H]([C@H](O[C@H]1N2C3=NC=NC(=C3N=C2Br)N)CO)O
  • Synonyms: 8-Bromo-2′-deoxyadenosine, 14985-44-5, Adenosine, 8-bromo-2′-deoxy-, 2′-Deoxy-8-bromoadenosine, 8-B-2-DA

Application

8-Bromo-2′-deoxyadenosine is widely used in biochemical research as a modified nucleoside for studying DNA repair mechanisms and enzyme specificity. It serves as a substrate for DNA polymerases and reverse transcriptases to investigate nucleotide incorporation kinetics. Researchers also employ this analog to explore the structural and functional impacts of halogenated bases on nucleic acid duplex stability and protein binding.

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