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Atomfair 5′-o-(4,4-dimethoxytrityl)-thymidine-3′-succinate, tea salt 5′-O-DMT-thymidine-3′-succinate TEA salt C41H51N3O10

Description 5′-O-(4,4-Dimethoxytrityl)-thymidine-3′-succinate, TEA salt (CAS No. 402944-22-3) is a high-purity, synthetic nucleoside derivative widely used in oligonucleotide synthesis and pharmaceutical research. This compound features a 5′-O-DMT (4,4′-dimethoxytrityl) protecting group, a 3′-succinate linker, and is supplied as a triethylammonium (TEA) salt for enhanced solubility and stability. With the molecular formula C41H51N3O10, it is a critical intermediate in solid-phase DNA/RNA synthesis, enabling the controlled elongation of oligonucleotide chains. Ideal for researchers, this product is rigorously tested by HPLC and NMR to ensure ??95% purity, making it suitable for demanding applications in genomics, diagnostics, and therapeutic development. Store desiccated at -20??C to maintain…

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Description

Description

5′-O-(4,4-Dimethoxytrityl)-thymidine-3′-succinate, TEA salt (CAS No. 402944-22-3) is a high-purity, synthetic nucleoside derivative widely used in oligonucleotide synthesis and pharmaceutical research. This compound features a 5′-O-DMT (4,4′-dimethoxytrityl) protecting group, a 3′-succinate linker, and is supplied as a triethylammonium (TEA) salt for enhanced solubility and stability. With the molecular formula C41H51N3O10, it is a critical intermediate in solid-phase DNA/RNA synthesis, enabling the controlled elongation of oligonucleotide chains. Ideal for researchers, this product is rigorously tested by HPLC and NMR to ensure ??95% purity, making it suitable for demanding applications in genomics, diagnostics, and therapeutic development. Store desiccated at -20??C to maintain optimal performance.

  • CAS No: 402944-22-3
  • Molecular Formula: C41H51N3O10
  • Molecular Weight: 745.9
  • Exact Mass: 745.35744483
  • Monoisotopic Mass: 745.35744483
  • IUPAC Name: 4-[(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine
  • SMILES: CCN(CC)CC.CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OC(=O)CCC(=O)O
  • Synonyms: 402944-22-3, 5′-O-(4,4-Dimethoxytrityl)-thymidine-3′-succinate, TEA salt, 933-444-7, 5′-O-Dmt-thymidine 3′-o-succinate triethylammonium salt, 5′-O-(4,4′-dimethoxytrityl)-thymidine-3′-O-succinic acid triethylammonium salt

Application

This compound is primarily used as a building block in oligonucleotide synthesis, particularly in the automated solid-phase synthesis of DNA/RNA sequences. The DMT group protects the 5′-hydroxyl during chain elongation, while the 3′-succinate linker facilitates covalent attachment to solid supports (e.g., CPG or polystyrene resins). Its TEA salt form improves solubility in organic solvents like acetonitrile, essential for phosphoramidite chemistry. Applications include antisense drug development, PCR primer synthesis, and probe design for molecular diagnostics.

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