Description

Description

5-Bromo-2-fluoro-1,3-dimethylbenzene (CAS No. 14659-58-6) is a high-purity halogenated aromatic compound with the molecular formula C₈H₈BrF. This specialized chemical is a valuable intermediate in organic synthesis, particularly in pharmaceutical and agrochemical research. The compound features a bromine and fluorine substitution on a dimethylbenzene backbone, offering unique reactivity for cross-coupling reactions such as Suzuki-Miyaura or Buchwald-Hartwig amination.

Our product is rigorously tested to ensure >98% purity (GC) and is supplied in sealed, light-resistant containers under inert atmosphere to guarantee stability. Ideal for medicinal chemistry applications, this building block enables the introduction of both bromo and fluoro functional groups in a single step, streamlining synthetic routes.

Key specifications:

• Molecular Weight: 203.05 g/mol
• Appearance: Colorless to pale yellow liquid
• Boiling Point: ~215-220??C
• Density: ~1.45 g/cm³
• Storage: 2-8??C under nitrogen

Application

5-Bromo-2-fluoro-1,3-dimethylbenzene serves as a versatile building block in pharmaceutical research, particularly for developing kinase inhibitors and CNS-active compounds. The bromine moiety facilitates palladium-catalyzed cross-coupling reactions, while the fluorine atom can enhance metabolic stability in drug candidates. Researchers utilize this compound in structure-activity relationship studies to optimize bioactivity profiles. It’s also employed in material science for creating specialized liquid crystals and organic electronic materials.

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