Description

4-Bromo-2-fluoropyridine (CAS No. 128071-98-7) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₃BrFN. This heterocyclic compound features a bromine substituent at the 4-position and a fluorine atom at the 2-position of the pyridine ring, offering versatile reactivity for cross-coupling reactions, nucleophilic substitutions, and pharmaceutical intermediate synthesis. Ideal for researchers in medicinal chemistry and material science, this compound is supplied as a clear to pale-yellow liquid (or low-melting solid) with ≥95% purity (GC). Store under inert atmosphere at 2-8°C to prevent degradation. Compatible with Suzuki-Miyaura, Buchwald-Hartwig, and SNAr reactions.

Properties

• CAS Number: 128071-98-7
• Complexity: 78.8
• IUPAC Name: 4-bromo-2-fluoro-pyridine
• InChI: InChI=1S/C5H3BrFN/c6-4-1-2-8-5(7)3-4/h1-3H
• InChI Key: PTPTZLXZHPPVKG-UHFFFAOYSA-N
• Exact Mass: 174.94329
• Molecular Formula: C5H3BrFN
• Molecular Weight: 175.99
• SMILES: C1=CN=C(C=C1Br)F
• Topological: 12.9
• Monoisotopic Mass: 174.94329
• Synonyms: 4-Bromo-2-fluoropyridine, 128071-98-7, DTXSID00376510, DTXCID10327538, 672-942-6, 2-Fluoro-4-bromopyridine, Pyridine, 4-bromo-2-fluoro-, 4-bromo-2-fluoro-pyridine, MFCD04112504, 4-bromo-2-fluoro pyridine, SCHEMBL255652, SCHEMBL4921181, SCHEMBL4921310, 4-bromanyl-2-fluoranyl-pyridine, 4-Bromo-2-fluoropyridine, 97%, PTPTZLXZHPPVKG-UHFFFAOYSA-N, BCP26033, CS-D0936, SBB089106, AKOS005064011, AB17567, AC-5167, FB08153, PS-8593, HY-32742, SY005160, DB-006698, B4778, EN300-87237, A805782, 2-Fluoro-4-bromopyridine;Pyridine, 4-bromo-2-fluoro-, F0001-3399

Application

4-Bromo-2-fluoropyridine serves as a key building block in the synthesis of agrochemicals, pharmaceuticals, and ligands for catalysis. Its electron-deficient pyridine ring facilitates regioselective functionalization, making it valuable for kinase inhibitor development and PET tracer precursors. The compound is also used in metal-organic framework (MOF) design and functional material research.

Safety and Hazards

GHS Hazard Statements

• H302 (95.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (10.2%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (98%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (83.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (14.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (12.2%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (95.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P262, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (95.9%)
• Acute Tox. 3 (10.2%)
• Skin Irrit. 2 (98%)
• Eye Dam. 1 (83.7%)
• Eye Irrit. 2A (14.3%)
• Acute Tox. 4 (12.2%)
• STOT SE 3 (95.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.