Description

Description

3,5-Difluorobenzyl bromide (CAS 141776-91-2) is a high-purity aromatic bromide compound with the molecular formula C₇H₅BrF₂. This organofluorine building block features a reactive benzyl bromide group flanked by two fluorine atoms at the 3- and 5-positions, making it an excellent electrophile for nucleophilic substitution reactions. The compound is supplied as a clear to pale yellow liquid with typical purity >95% (GC), packaged under inert gas to prevent degradation. Ideal for pharmaceutical intermediates, agrochemical synthesis, and materials science applications requiring selective fluorination. Proper storage at 2-8??C in amber vials is recommended to maintain stability. Hazard classification includes skin/eye irritant and moisture-sensitive properties – handle with appropriate PPE in a fume hood.

Application

3,5-Difluorobenzyl bromide serves as a key synthetic intermediate for introducing difluorobenzyl motifs in medicinal chemistry. The compound is particularly valuable in the development of kinase inhibitors and CNS-active pharmaceuticals where fluorine substitution modulates bioavailability. In material science, it acts as a precursor for liquid crystals and fluorinated polymers. The reactive benzyl bromide group enables facile coupling reactions in Pd-catalyzed cross-couplings or nucleophilic substitutions.

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