Description

Description

3-Chloro-5-fluorophenol (CAS No. 202982-70-5) is a high-purity halogenated phenol derivative with the molecular formula C₆H₄ClFO. This compound is a valuable building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring both chloro and fluoro substituents on the aromatic ring, enables precise modulation of electronic and steric properties in target molecules. Available in ??98% purity (GC), this reagent is supplied in sealed glass vials under inert atmosphere to ensure stability. Suitable for use in cross-coupling reactions, nucleophilic substitutions, and as a precursor for advanced intermediates. Technical specifications include: molecular weight 146.55 g/mol, melting point 40-42??C, and boiling point 210-212??C. Store at 2-8??C in a dry, well-ventilated area.

Application

3-Chloro-5-fluorophenol serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) with antimicrobial and antifungal properties. Researchers utilize this compound in Suzuki-Miyaura coupling reactions to create biaryl structures for drug discovery. Its electron-withdrawing substituents make it particularly useful in designing kinase inhibitors and PET radiotracer precursors. The compound also finds application in material science as a monomer for specialty polymers with enhanced thermal stability.

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