Description

Description

3-Bromo-4-methylpyridine (CAS No. 22282-99-1) is a high-purity heterocyclic organic compound with the molecular formula C₆H₆BrN. This brominated pyridine derivative is a versatile building block in pharmaceutical, agrochemical, and material science research. The compound features a reactive bromine substituent at the 3-position and a methyl group at the 4-position of the pyridine ring, enabling diverse functionalization via cross-coupling reactions, nucleophilic substitutions, and metal-catalyzed transformations.

Our product is synthesized under strict quality control, ensuring >98% purity (HPLC/GC) and is supplied as a clear to pale yellow liquid or crystalline solid. It is packaged under inert gas to maintain stability and is ideal for use in Suzuki-Miyaura, Buchwald-Hartwig, and other palladium-catalyzed reactions. Available in quantities ranging from grams to kilograms, this compound is a critical intermediate for developing active pharmaceutical ingredients (APIs), ligands, and specialty chemicals.

Key Specifications:
– CAS: 22282-99-1
– Molecular Weight: 172.02 g/mol
– Melting Point: ~25-30??C (varies by form)
– Boiling Point: ~220-225??C
– Storage: 2-8??C under inert atmosphere

Application

3-Bromo-4-methylpyridine serves as a key intermediate in the synthesis of pharmaceuticals, particularly for kinase inhibitors and CNS-active compounds. Its reactive bromine moiety allows for efficient cross-coupling in palladium-catalyzed reactions to construct complex heterocycles. Researchers also utilize it in agrochemical development for crop protection agents and in material science for designing functionalized pyridine-based ligands. The methyl group enhances electron density, making it valuable for tuning electronic properties in catalytic systems.

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