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Atomfair 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine C6H3Cl2N3

Description 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine (CAS No. 63200-54-4) is a high-purity heterocyclic compound with the molecular formula C6H3Cl2N3. This chlorinated pyrrolopyrimidine derivative is a versatile building block in medicinal chemistry and pharmaceutical research, particularly for the synthesis of nucleoside analogs and kinase inhibitors. Its rigid bicyclic structure and reactive chloro substituents make it an ideal intermediate for cross-coupling reactions, nucleophilic substitutions, and other functionalizations. The compound is supplied as an off-white to light yellow crystalline powder with ??95% purity (HPLC), ensuring consistency for demanding synthetic applications. Proper storage at 2-8??C under inert atmosphere is recommended to maintain stability.

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Description

Description

2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine (CAS No. 63200-54-4) is a high-purity heterocyclic compound with the molecular formula C6H3Cl2N3. This chlorinated pyrrolopyrimidine derivative is a versatile building block in medicinal chemistry and pharmaceutical research, particularly for the synthesis of nucleoside analogs and kinase inhibitors. Its rigid bicyclic structure and reactive chloro substituents make it an ideal intermediate for cross-coupling reactions, nucleophilic substitutions, and other functionalizations. The compound is supplied as an off-white to light yellow crystalline powder with ??95% purity (HPLC), ensuring consistency for demanding synthetic applications. Proper storage at 2-8??C under inert atmosphere is recommended to maintain stability.

  • CAS No: 63200-54-4
  • Molecular Formula: C6H3Cl2N3
  • Molecular Weight: 188.01
  • Exact Mass: 186.9704025
  • Monoisotopic Mass: 186.9704025
  • IUPAC Name: 2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine
  • SMILES: C1=CNC2=C1N=C(N=C2Cl)Cl
  • Synonyms: 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine, DTXSID20418749, 2,4-dichloro-5H-pyrrolo(3,2-d)pyrimidine, DTXCID30369596, 810-549-5

Application

2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine serves as a key precursor in the synthesis of adenosine receptor antagonists and anticancer agents targeting purine-binding enzymes. Researchers utilize this scaffold to develop novel kinase inhibitors for tyrosine and serine/threonine kinases through selective substitution at the 2- and 4-positions. In drug discovery programs, it enables rapid generation of compound libraries via Suzuki-Miyaura and Buchwald-Hartwig coupling reactions. The dichloro functionality allows sequential functionalization, making it valuable for structure-activity relationship studies in lead optimization.

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