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Atomfair 2-(Trifluoromethyl)benzylic alcohol C8H7F3O

Description 2-(Trifluoromethyl)benzylic alcohol (CAS No. 2106-18-5) is a high-purity fluorinated aromatic alcohol with the molecular formula C8H7F3O. This compound, also known as [2-(trifluoromethyl)phenyl]methanol, is a versatile building block in organic synthesis and pharmaceutical research. Its unique trifluoromethyl group enhances lipophilicity and metabolic stability, making it valuable for medicinal chemistry applications. The product is supplied as a clear, colorless to pale yellow liquid with a characteristic aromatic odor. It is rigorously tested for purity (typically ??97% by GC) and is packaged under inert gas to ensure stability. Suitable for use in Grignard reactions, esterifications, and as a precursor for chiral auxiliaries.

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Description

Description

2-(Trifluoromethyl)benzylic alcohol (CAS No. 2106-18-5) is a high-purity fluorinated aromatic alcohol with the molecular formula C8H7F3O. This compound, also known as [2-(trifluoromethyl)phenyl]methanol, is a versatile building block in organic synthesis and pharmaceutical research. Its unique trifluoromethyl group enhances lipophilicity and metabolic stability, making it valuable for medicinal chemistry applications. The product is supplied as a clear, colorless to pale yellow liquid with a characteristic aromatic odor. It is rigorously tested for purity (typically ??97% by GC) and is packaged under inert gas to ensure stability. Suitable for use in Grignard reactions, esterifications, and as a precursor for chiral auxiliaries.

  • CAS No: 2106-18-5
  • Molecular Formula: C8H7F3O
  • Molecular Weight: 176.14
  • Exact Mass: 176.04489933
  • Monoisotopic Mass: 176.04489933
  • IUPAC Name: [2-(trifluoromethyl)phenyl]methanol
  • SMILES: C1=CC=C(C(=C1)CO)C(F)(F)F
  • Synonyms: 346-06-5, 2-(Trifluoromethyl)benzylic alcohol, 2-(Trifluoromethyl)benzenemethanol, EINECS 206-467-9, DTXSID10188166

Application

2-(Trifluoromethyl)benzylic alcohol is widely used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and liquid crystals. Its trifluoromethyl group is particularly valuable in drug design for improving bioavailability and binding affinity. The compound serves as a key precursor for catalysts and ligands in asymmetric synthesis. Researchers also utilize it to modify the physicochemical properties of lead compounds in medicinal chemistry programs.

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